Retrotransposition of Limited Deletion Type of Intracisternal A-particle Elements in the Myeloid Leukemia Clls of C3H/He Mice
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概要
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The murine genome has about 1,000 copies of DNA elements for the intracisternal A-particle (IAP) that resembles a retrovirus. We previously reported that the genomic DNA of the cells from radiation-induced acute myeloid leukemia (AML) lines derived from C3H/He inbred mice was frequently rearranged by the integration of the IAP element. In this study, 8 IAP elements from the characteristic integration sites in 6 cell lines of radiation-induced AML from different mice were characterized and compared in structure with 114 IAP elements isolated from the normal C3H/He genome. One of the 8 elements was a full-length type I IAP, and 7 were of type-IΔ1 with a common deletion site. Although the type IΔ1 form is a minor population accounting for about 6% of total genomic IAP elements, it is predominantly retrotransposed in the AML cells from different C3H/He mice. This indicates that limited populations of the IAP elements contribute to the unique retrotransposition in AML cells.
- 日本放射線影響学会の論文
著者
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Tanaka Izumi
放射線医学総合研究所緊急被ばく医療研究センター
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Ishihara Hiroshi
放射線医学総合研究所緊急被ばく医療研究センター
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Tanaka Izumi
Natl. Inst. Radiol. Sci.
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Tanaka Izumi
Redox Regulation Research Group
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ISHIHARA Hiroshi
Natl. Inst. Radiol. Sci.
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Yoshida Kazuko
Div. Radiobiol. Biodosim. Natl. Inst. Radiol. Sci.
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Yoshida Kazuko
Radiation Hazard Research Group Radiation Safety Research Center National Institute Of Radiological
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Ishihara Hiroshi
Redox Regulation Research Group
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WAN Hong
Redox Regulation Research Group
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NOJIMA Kumie
International Space Radiation Laboratory
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Wan Hong
放射線医学総合研究所
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Wan Hong
Redox Regulation Research Group:(present Address)beijing Neurosurgical Institute
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Nojima Kumie
International Space And Radiation Laboratory National Institute Of Radiological Sciences
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Tanaka Izumi
Redox Regul. Res. Group Natl. Inst. Radiol. Sci.
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Ishihara H
名古屋大学 第1内科
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Yoshida Kazuko
Radiat. Hazards Natl. Inst. Radiol. Sci.
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Ishihara H
Redox Regulation Research Group
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Yoshida Kazuko
Radiation Hazard Research Group Radiation Safety Research Center National Institute Of Radiological
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Ishihara Hiroshi
Redox Regul. Res. Group Natl. Inst. Radiol. Sci.
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