Intestinal Tumorigenicity of Mice Carrying Hemizygous Pax6, Pax6Sey-4H
スポンサーリンク
概要
- 論文の詳細を見る
The genotype-phenotype relationship in mice was examined experimentally using one of the small eye mutants, Pax6Sey-4H, which deletes the chromosome 2 middle region, hemizygously. The genotyping indicated that the deleted region starts at a site 102.60 Mb from the centromere and has a length of 6.51 Mb, in which 12 known and 27 novel genes are located. Expecting the development of myeloid leukemia, gamma-irradiation was performed to female mutants at the age of 10 weeks. The mutants did not develop myeloid leukemia during the observation period of 18 months. Instead, they developed tumors in the alimentary tract spontaneously (56.0%). The tumor latency was shortened by the radiation exposure, but the tumor incidence of the gamma-irradiated group (62.5%) was as high as that of spontaneously developing tumors. Intraductal proliferation of the epithelium of the Wirsung duct was observed in the gamma-irradiated mutants (18.8%). Considering the results of the Pax6Sey-4H mutant together with those of another small eye mutant, Pax6Sey-3H, the anomaly and the tumorigenicity of the intestinal tract were closely related to the hemizygosity of the 3.2 Mb segment of chromosome 2, where both mutants show a common deletion.
- Japanese Association for Laboratory Animal Scienceの論文
著者
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Nitta Yumiko
International Radiation Information Center Hiroshima University
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Nakagata Naomi
Center For Animal Resources And Dev. Kumamoto Univ.
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ISHIZAKI Fumiko
Department of Communication Disability, Faculty of Health Science, Hiroshima Prefectural University
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Yoshida Kazuko
Radiat. Hazards Natl. Inst. Radiol. Sci.
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Harada Toshihide
Department Of Health Services Management Faculty Of Health And Welfare Hiroshima International Unive
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YOSHIDA Kazuko
Radiation Hazards Research Group, National Institute for Radiological Science
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ISHIZAKI Fumiko
Department of Health Science, Hiroshima Prefectural University
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NITTA Kohsaku
Senogawa Hospital
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NITTA Yumiko
International Radiation Information Center, Research Institute for Radiation Biology and Medicine
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