Effects of High Linear Energy Transfer Radiation on the Cochlea of C3H/He Mouse During Postnatal Developmental Course

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概要

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• To investigate the biological effectiveness of neutrons at energies below 1MeV with regard to ear toxicity, we exposed mice to 1.0 Gy of monoenergetic neutrons (1.026MeV) or ^<137>Cs gamma rays at 7 days of age, and observed subsequent morphological changes in the inner ear with light and scanning electron microscopes. Monoenergetic neutrons, but not gamma rays, caused acute changes in the ear. The epithelium of the greater epithelial ridge in the organ of Corti showed degeneration around 6hours and disappeared by 72hours post-irradiation. The apoptotic cell death of the epithelium of the greater epithelial ridge was inducible by the radiation at 3 or 4 days of age. The hair cells formed the protrusion structures of the surface by 72hours post-irradiation. Neutron-irradiation also caused acute otitis media until 10weeks of age.

• 日本放射線影響学会の論文
• 2005-03-25

著者

• Nitta Yumiko

  Department Of Food And Nutrition Suzugamine Women's College

• Nitta Yumiko

  International Radiation Information Center Hiroshima University

• ARAKI NOBUKAZU

  Department of Anatomy, Faculty of Medicine, Kyoto University

• HARADA Toshihide

  Department of Medical Management, Faculty of Health Services Management, Hiroshima International Uni

• Nitta Kohsaku

  Shiraki-no-sato

• Ishizaki Fumiko

  Faculty Of Health And Welfare Prefectural University Of Hiroshima

• Ishizaki Fumiko

  Hiroshima Prefectural College Of Health And Welfare

• Araki Nobukazu

  Department Of Histology And Cell Biology Faculty Of Medicine Kagawa University

• Araki Nobukazu

  Department Of Anatany Faculty Of Medicine Kyoto University

• NITTA Kohsaku

  Ohtani Rehabilitation Hospital

• ANDO Juko

  Department of Education, Faculty of Letters, Keio University

• Ando Juko

  Department Of Education Faculty Of Letters Keio University

• Harada Toshihide

  Department Of Health Services Management Hiroshima International University

• Harada Toshihide

  Department Of Health Services Management Faculty Of Health And Welfare Hiroshima International Unive

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