PROTECTIVE EFFECT OF COENZYME Q_<10> AGAINST THE ADVERSE REACTION OF MITOMYCIN C IN MOUSE LIVER

概要

論文の詳細を見る
The sidc effects of mitomycin C (MMC) on liver cells and the protective effectiveness were investigated morphologically, biochemically and histo-cytochemically. Coenzyme Q_<10>(CoQ_<10>) prevented the cells from inflation, mitochondria swelling and vacuolation of endoplasmic reticulum, which were caused by the administration of MMC . This might be due to CoQ_<10> preventing the cells from decreasing energy metabolism. The biochemical determination of enzyme activities indicated significant deifference between the treatments in 5'-nucleotidase (5'-Nase) activity and in contrast, Mg^<++>-adenosine triphosphatase (Mg^<++>-ATPasc) was not found statistically different. The histo-cytochemical observation showed that the activity of 5'-Nase and Mg^<++>-ATPase were decreased by being treated with MMC. But the localization pattern of thc enzyme activities was not diffierent from the control when both CoQ_<10> and MMC were administrated. The present results suggested that CoQ_<10> could prevent damage caused by antineoplastic agents.
日本組織細胞化学会の論文