THE RELATIONSHIP BETWEEN HETEROPHAGY AND AUTOPHAGY IN THE SPLENIC MACROPHAGE OF RATS AFTER γ-RAY IRRADIATION
スポンサーリンク
概要
- 論文の詳細を見る
Ultrastructural changes of splenic macrophages of rats after γ-ray irradiation were investigated, especially focused on lysosomal behaviors together with the cytochemical demonstration of acid phosphatase (AcPase) activity. γ-ray irradiation (total 800 rads) caused extensive phagocytosis in splenic macrophages. Damaged lymphocytes and erythrocytes were massively phagocytosed by these macrophages. The large number of heterophagosomes thus formed within macrophages subsequently acquired AcPase activity and converted to large heterophagolysosomes (HPL). Then, some portions of large HPL started to show constrictions which resulted in the separation and formation of many small lysosomes. Some of large HPL further became flattened and projected pseudopod-like processes which surrounded some cytoplasmic area or organelles of macrophage, especially small lysosomes, forming autophagolysosomes. These lysosomal behaviors may be related to the regulation or self-control of the lysosomal system within macrophages.
- 日本組織細胞化学会の論文
著者
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Ono Koji
Department of Cardiology, Gifu Prefectural General Medical Center
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Ogawa Kazuo
Department of Cardiology, Jikei University
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Ono Koji
Department Of Cardiology Gifu Prefectural General Medical Center
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ABE Mitsuyuki
Department of Radiology, Faculty of Medicine
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Ono Koji
Department Of Radiology Faculty Of Medicine Kyoto University
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Piao Ying
Department Of Computer Science And Department Of Central Laboratory The First Medical College Of Pla
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Piao Ying
Department Of Anatomy Faculty Of Medicine Kyoto University
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Abe Mitsuyuki
Department Of Radiology Faculty Of Medicine Kyoto University
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Ogawa Kazuo
Department Of Anatomy Faculty Of Medicine Kyoto University
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Ogawa Kazuo
Department Of Anatany Faculty Of Medicine Kyoto University
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Abe Mitsuyuki
Department Of Radiology Faculty Of Medicine
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