MORPHOMETRIC ANALYSIS OF GAP JUNCTIONS IN THE RAT LENS DURING CATARACT FORMATION
スポンサーリンク
概要
- 論文の詳細を見る
In order to investigate the ultrastructural and quantitative changes of gap junctions in the lens associated with cataract formation, the lenses of ICR (Ihara cataract rat)-strain rats which invariably develop cataracts and of Wistar rats were analyzed morphometrically. Gap junctions were observed abundantly in lenses of normal Wistar rats. In lenses of ICR-strain rats, it became difficult to detect gap junctions in accordance with cataract formation. However, no notable differences were detected in the ultrastructure of gap junctions between both lenses of control and ICR-strain rats. Morphometric analysis revealed that the ratio of total length to cell circumference at 4 weeks of age (before cataract formation) is mostly equal to that of age-matched controls (11%). The ratio decreased to 7% for 9-week-old ICR-strain rats (just before cataract formation) and 2% for 16-week-old ICR-strain rats (after cataract formation). These results suggest that the decrease insize and frequency of gap junctions prior to cataract formation may be linked with the steps leading to cataractogenesis.
- 日本組織細胞化学会の論文
著者
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Ogawa Kazuo
Department of Cardiology, Jikei University
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Tanaka Toshikazu
Department of Cardiology, Okazaki City Hospital
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Sakai M
Kyushu Univ. Fukuoka Jpn
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Sakai M
Department Of Anatomy Faculty Of Medicine Kyoto University
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Tanaka Toshikazu
Department Of Anatomy Faculty Of Medicine Kyoto University
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FUJIMOTO KAZUSHI
Department of Anatomy, Faculty of Medicine, Kyoto University
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Tanaka Takaaki
Department Of Oral Surgery Asahi University School Of Dentistry
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Sakai Masahiro
Department Of Anatomy Faculty Of Medicine Kyoto University
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Ogawa K
Department Of Veterinary Anatomy Graduate School Of Agriculture And Biological Sciences Osaka Prefec
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Fujimoto T
Department Of Anatomy And Molecular Cell Biology Nagoya University Graduate School Of Medicine
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Tanaka T
Department Of Oral Anatomy And Cell Biology Graduate School Of Dental Sciences Kyushu University
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Fujimoto K
Department Of Biochemistry Meikai University School Of Dentistry
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Fujimoto Kazushi
Department Of Anatomy And Neurobiology Graduate School Of Medicine Kyoto University
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Tanaka Tomoo
Division Of Basic Medical Sciences Tokai University School Of Medicine
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Sakai M
Laboratory Of Forest Policy Division Of Forest Environment And Management Sciences Department Of For
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Ogawa Kazuo
Department Of Anatomy Faculty Of Medicine Kyoto University
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Fujimoto Kazushi
Section Of Physiological Anatomy Fukui Prefectural University Faculty Of Nursing And Welfare Laborat
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Ogawa Kazuo
Department Of Anatany Faculty Of Medicine Kyoto University
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