Timing in Administration of a Heat-killed Lactobacillus casei Preparation for Radioprotection in Mice
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概要
- 論文の詳細を見る
A single subcutaneous injection of a preparation of heat-killed Lactobacillus casei (LC 9018), given before or after irradiation, significantly increased the survival rate of mice that had received 8.5-Gy ^<137>Cs whole-body γ-irradiation. A similar radioprotective effect was observed when LC 9018 was administered within the period from 2 days before irradiation to 9 h after irradiation, the pre-irradiation treatment being slightly better than the post-irradiation treatment. Increases in the weight of the spleen and in the number of endogenous spleen colonies on days 8 and 12 after irradiation suggested that the radioprotective effect was based on enhanced recovery of hematopoietic tissues. The activity of macrophage colony-stimulating factor (M-CSF) in serum was rapidly increased by the treatment and was maintained at the elevated level for 13 days. At the same time, an increased level of M-CSF mRNA was detected in the livers of the treated mice.
- 日本放射線影響学会の論文
著者
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Ishihara Hiroshi
放射線医学総合研究所緊急被ばく医療研究センター
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Nomoto Koji
Yakult Central Institute for Microbiological Research
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ISHIHARA Hiroshi
Natl. Inst. Radiol. Sci.
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常岡 和子
放射線医学総合研究所薬学研究部
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Yokokura Teruo
Yakult Central Institute For Microbiological Research
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Yokokura Teruo
Yakult Cent. Inst. Miorobiol.
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常岡 和子
放射線医学総合研究所薬理科学研究部
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Ishihara H
名古屋大学 第1内科
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Shikita Mikio
放射線医学総合研究所薬理科学研究部
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Ishihara H
Redox Regulation Research Group
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DIMCHEV ALEXANDER
放射線医学総合研究所薬理科学研究部
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Nomoto Koji
Yakult Central Inst. For Microbiological Res. Tokyo Jpn
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