Whole-body X-irradiation Induces Acute and Transient Expression of Heme Oxygenase-1 in Rat Liver
スポンサーリンク
概要
- 論文の詳細を見る
Activation of the stress-inducible heme oxygenase-1 (HO-1) gene by X-irradiation was investigated in rat liver. When male Wistar MS strain rats (8 weeks) received whole-body irradiation of 17.0 Gy, 7 h later the activity of heme oxygenase in the liver was significantly enhanced (2.5 times). The level of HO-1 mRNA expression was increased by 2.3 and 4.0 times 2 and 4 h after radiation, and then declined at 7 and 10 h to the level of 2.0 and 1.6 times of the control. When the X-ray dose was varied from 4.0 to 21.7 Gy, the transcription of the gene was enhanced at all doses and the level of activation was dose-dependent. Finally, western blotting of irradiated liver demonstrated a significant increase in the level of HO-1 induced by X-rays, peaking at 4 h. Thus, X-rays were confirmed to be stressors that induce acute HO-1 expression transiently in the liver.
- 日本放射線影響学会の論文
著者
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Kugawa Fumihiko
Department of Biopharmaceutics, School of Pharmacy, Hyogo University of Health Sciences
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Ishihara Hiroshi
放射線医学総合研究所緊急被ばく医療研究センター
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Mori M
Department Of Oral-maxillofacial Surgery Asahi University School Of Dentistry:medicaraise Corporatio
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Mori Masahiko
Department Of Oral Pathology Osaka Dental University
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ISHIHARA Hiroshi
Natl. Inst. Radiol. Sci.
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Ishihara Hiroshi
Redox Regulation Research Group
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SUZUKI Keiko
Redox Regul. Res. Group, Natl. Inst. Radiol. Sci.
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Mori M
Department Of Oral And Maxillofacial Surgery School Of Dentistry Asahi University
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Mori M
Department Of Oral Surgery Asahi University School Of Dentistry
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Mori M
Department Of Oral Surgery Gifu College Of Dentistry
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Kugawa Fumihiko
Department Of Biological Pharmaceutical Sciences College Of Pharmacy Nihon Univ.
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MORI MASAHIKO
Radiation Hazard Research Group, National Institute of Radiological Sciences
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Mori Masahiko
Takasago Research & Development Center Mitsubishi Heavy Industries Ltd.
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Mori Masahiko
Radiation Hazards Research Group National Institute Of Radiological Sciences
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Mori Masahiro
Radiation Hazard Research Group National Institute Of Radiological Sciences
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Ishihara H
名古屋大学 第1内科
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Suzuki K
Course Of Life Sciences And Radiation Research Graduate School Of Biomedical Sciences Nagasaki Unive
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Ishihara H
Redox Regulation Research Group
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Suzuki K
Redox Regulation Research Group National Institute Of Radiological Sciences
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Muto Masahiro
Department Of Oral Pathology Osaka Dental University
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Ishihara Hiroshi
Redox Regul. Res. Group Natl. Inst. Radiol. Sci.
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Mori Masahiko
Radiation Effect Mechanisms Research Group Research Center For Radiation Protection National Institute Of Radiological Sciences
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