Studies on Agents with Vasodilator and β-Blocking Activities. II
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概要
- 論文の詳細を見る
A series of phenoxypropanolamines having a hydrazinopyridazinyl moiety was synthesized. Their hypotensive and β-blocking activities were evaluated after intravenous administration of the compounds to anethetized rats.Some of them exhibited both activities. In particular, compound 20k is a candidate for clinical use due to its hypotensive activity, equal to that of hydralazine, and its β-blocking activity, 2.7-fold more potent than that of propranolol.
- 社団法人日本薬学会の論文
- 1995-02-15
著者
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石森 勉
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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安田 喜久男
Research Laboratory, Teikoku Hormone Mfg. Co., Ltd.
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安田 喜久男
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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関 敏美
Research Division, Teikoku Hormone Manufacturing Co., Ltd.,
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竹崎 孝行
Research Division, Teikoku Hormone Manufacturing Co., Ltd.,
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大内 力男
Research Division, Teikoku Hormone Manufacturing Co., Ltd.,
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斎藤 守信
Research Division, Teikoku Hormone Manufacturing Co., Ltd.,
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大藪 宏
Research Division, Teikoku Hormone Manufacturing Co., Ltd.,
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谷本 由隆
Research Division, Teikoku Hormone Manufacturing Co., Ltd.,
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山口 隆
Research Division, Teikoku Hormone Manufacturing Co., Ltd.,
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Seki Taiichiro
Lab. Of Nutrition And Physiology Dep. Of Chemistry And Life Sci. Nihon Univ. Coll. Of Bioresource Sc
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Seki T
Department Of Nutrition And Physiology Nihon University College Of Bioresource Sciences
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関 敏美
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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Saitoh Makiko
Faculty Of Pharmaceutical Sciences Kanazawa University
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大内 力男
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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大藪 宏
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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Tanimoto Y
Tokyo Dental Coll. Chiba
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竹崎 孝行
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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斎藤 守信
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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谷本 由隆
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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山口 隆
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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Yamaguchi Takashi
Research Division Teikoku Hormone Manufacturing Co. Ltd
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Yamashita K
Faculty Of Pharmaceutical Sciences Okayama University
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