Benzodiazepine Receptor Agonists Modulate Thymocyte Apoptosis Through Reduction of the Mitochondrial Transmembrane Potential
スポンサーリンク
概要
- 論文の詳細を見る
Peripheral-type benzodiazepines have been shown to exert immunological effects. In this study, we examined the effects of the peripheral-type benzodiazepines on murine thymocytes. Murine thymocytes that were incubated with the peripheral-type benzodiazepines underwent apoptosis associated with the collapse of mitochondrial transmembrane potential (Δφm). The drugs stimulated dexamethasone- and etoposide-induced apoptosis with the enhanced collapse of Δφm. The central-type benzodiazepines had no effect on either the Δφm or apoptosis. The reduction of Δφm depended on protein synthesis and protein phosphorylation. These results suggest that the immunomodulating effect of benzodiazepines is in part due to the modulation of thymocyte apoptosis associated with the collapse of Δφm.
- 社団法人 日本薬理学会の論文
- 1999-02-01
著者
-
SATO Yutaka
Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nago
-
Kizaki Harutoshi
Department of Biochemistry,Tokyo Dental College
-
Kizaki Harutoshi
Department Of Biochemistry Tokyo Dental College
-
Kizaki Harutoshi
Department Of Biochemistry Tokyo Dental College : Oral Health Science Center Tokyo Dental College
-
Sakurai Yoshiaki
Hitachi Device Engineering Co. Ltd.
-
Sato Yutaka
Department Of Biological Mechanisms And Functions Graduate School Of Bioagricultural Sciences Nagoya
-
TANIMOTO Yutaka
Department of Biochemistry, Tokyo Dental College
-
ONISHI Yoshiaki
Department of Biochemistry, Tokyo Dental College
-
Tanimoto Y
Tokyo Dental Coll. Chiba
-
Tanimoto Yutaka
Department Of Biochemistry Tokyo Dental College
-
谷本 由隆
Research Division Teikoku Hormone Manufacturing Co. Ltd.
-
Sato Y
Tokyo Metropolitan Inst. Gerontology Tokyo
-
Sato Yutaka
Department Of Biochemistry And Oral Health Science Center Tokyo Dental College
-
Onishi Yuko
Dep. Of Biomolecular Engineering Graduate School Of Bioscience And Biotechnology Tokyo Inst. Of Tech
-
Onishi Yoshiaki
Department Of Biochemistry Tokyo Dental College
-
Sato Yutaka
Department of Applied Physics, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo 184-8588, Japan
関連論文
- Gateway Binary Vectors with the Bialaphos Resistance Gene, bar, as a Selection Marker for Plant Transformation
- Improvement of Transpassive Intergranular Corrosion Resistance of 304 Austenitic Stainless Steel by Thermomechanical Processing for Twin-induced Grain Boundary Engineering
- Single Nucleotide Polymorphisms (SNPs) Detected in the gbpC Gene Coding Region of Streptococcus mutans
- Modulation of dexamethasone-induced thymocyte apoptosis by heat-shock protein 90-binding agents
- Generation of duplication or deletion mutants in Streptococcus mutans following homologous recombination-mediated random mutagenesis by integrational vector pVA891
- The expression and localization of osteopontin in the mouse major salivary glands
- Studies on Agents with Vasodilator and β-Blocking Activities. II
- Noise Reduction Techniques for a 64kb ECL-CMOS SRAM with a 2ns Cycle Time (Special Issue on LSI Memories)
- Redundancy Technique for Ultra-High-Speed Static RAMs
- Ulitaprecision Machining Characteristics of Poly-Crystalline Germanium
- Ultraprecision Machining Characteristics of Poly-crystalline Germanium(Ultra-precision machining)
- Identification and Partial Amino Acid Sequences of Seven S-RNases Associated with Self-Incompatibility of Japanese Pear, Pyrus pyrifolia Nakai
- Characteristics of Microstructure in Ultrahigh Carbon Steel Produced during Friction Stir Welding
- Four gbpC Gene Homologues in Streptococcus sobrinus
- Expression of AMP-activated Protein Kinase Subunit Isoforms in Masseter and Tibialis Anterior Muscles of Mice before and after Weaning
- Evaluation of Human P-Glycoprotein (MDR1/ABCB1) ATPase Activity Assay Method by Comparing with in Vitro Transport Measurements : Michaelis-Menten Kinetic Analysis to Estimate the Affinity of P-Glycoprotein to Drugs(Biopharmacy)
- Pharmacogenomics of Drug Transporters : A New Approach to Functional Analysis of the Genetic Polymorphisms of ABCB1(P-Glycoprotein/MDR1)
- Functional Evaluation of ABCB1 (P-Glycoprotein) Polymorphisms : High-Speed Screening and Structure-Activity Relationship Analyses
- Improvement of Transpassive Intergranular Corrosion Resistance of 304 Austenitic Stainless Steel by Thermomechanical Processing for Twin-induced Grain Boundary Engineering
- Arrest of Intergranular Corrosion in Austenitic Stainless Steel by Twin-induced Grain Boundary Engineering(Student Poster Session)
- Novel Protein Kinase C δ Isoform Insensitive to Caspase-3
- Benzodiazepine Receptor Agonists Modulate Thymocyte Apoptosis Through Reduction of the Mitochondrial Transmembrane Potential
- Effects of Protein Tyrosine Kinase Inhibitors with Different Modes of Action on Topoisomerase Activity and Death of IL-2-Dependent CTLL-2 Cells
- Application of In Vitro Mutagenesis to Identify the Gene Responsible for Cold Agglutination Phenotype of Streptococcus mutans
- Gateway Binary Vectors with the Bialaphos Resistance Gene, bar, as a Selection Marker for Plant Transformation
- Mediastinal lymphatic drainage from pulmonary lobe based on CT observations of histoplasmosis : implications for minimal N2 disease of non-small-cell lung cancer
- The SHOOT ORGANIZATION2 Gene Coordinates Leaf Domain Development Along the Central-Marginal Axis in Rice
- Peptidyl Aldehyde Ingibitors of Proteasome Induce Apoptosis Rapidly in Mouse Lymphoma RVC Cells^1
- 316 EFFECT OF MICROSTRUCTRUE ON MECHANICAL PROPERTIES IN FRICTION STIR WELDED SUPER DUPLEX STAINLESS STEEL
- Microstructure and properties in dissimilar friction stir welded heat-resistant steels
- Microstructural Characterizations Following Friction Stir Welding of Dissimilar Alloys of Low- and High-Carbon Steels
- Evaluation of Ductile-Brittle Transition Temperature in Electron-Beam Welded Steel by Small Punch Test(Student Poster Session)
- Quantitative Analysis of Osteopontin Gene Expression Using a Real-Time Reverse Transcription-Polymerase Chain Reaction Assay
- Rice phenolics efflux transporter 2 (PEZ2) plays an important role in solubilizing apoplasmic iron(Plant nutrition)
- Proteasome Inhibitors Block Ras/ERK Signaling Pathway Resulting in the Downregulation of Fas Ligand Expression during Activation-Induced Cell Death in T Cells
- Fabrication of High Quality Ni1-xPtx Films for Use as Materials in High-Sensitivity Temperature Sensor
- Hardness and Micro-Texture in Friction Stir Welds of a Nanostructured Oxide Dispersion Strengthened Ferritic Steel
- The biochemistry of thymocyte apoptosis.
- Expression of the rice microRNA miR820 is associated with epigenetic modifications at its own locus
- Purine phosphoribosyltransferase activities in mouse tissues.
- FRICTION STIR WELDING OF FE-36WT%NI ALLOY
- Expression of the rice microRNA miR820 is associated with epigenetic modifications at its own locus
- Two WUSCHEL-related homeobox Genes, narrow leaf2 and narrow leaf3, Control Leaf Width in Rice