Modulation of dexamethasone-induced thymocyte apoptosis by heat-shock protein 90-binding agents
スポンサーリンク
概要
- 論文の詳細を見る
Heat-shock protein 90 (HSP90) is known to affect a variety of cellular activities. The present study showed that the HSP90-binding agents, geldanamycin, herbimycin A and radicicol, inhibited the murine thymocyte apoptosis induced by dexamethasone and was accompanied by the inhibition of the reduction of the mitochondrial transmembrane potential (ΔΨm). HSP90-binding agents did not inhibit etoposide-induced apoptosis. The inhibition of dexamethasone-induced apoptosis was in part due to the interference of HSP90 with the glucocorticoid receptor, resulting in the inhibition of nuclear translocation of the receptor. The expression of inositol 1, 4, 5-triphosphate receptors, which were shown to be involved in dexamethasone-induced apoptosis, did not participate in the inhibition of apoptosis.
- 東京歯科大学の論文
著者
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SATO Yutaka
Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nago
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佐藤 裕
東京歯科大学口腔科学センターhrc7
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Kizaki Harutoshi
Department of Biochemistry,Tokyo Dental College
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OHTA KAZUMASA
Department of Biochemistry, Tokyo Dental College
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OKOSHI RINTAROU
Department of Biochemistry, Tokyo Dental College
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WAKABAYASHI MAIKO
Department of Biochemistry, Tokyo Dental College
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Ohta Kazumasa
Department Of Biochemistry Tokyo Dental College
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Sato Y
Department Of Aging Medicine And Geriatrics Shinshu University School Of Medicine
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Okoshi Rintarou
Department Of Biochemistry Tokyo Dental College
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Kizaki Harutoshi
Department Of Biochemistry Tokyo Dental College
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Kizaki Harutoshi
Department Of Biochemistry Tokyo Dental College : Oral Health Science Center Tokyo Dental College
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Wakabayashi Maiko
Department Of Biochemistry Tokyo Dental College
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Okamoto-shibayama Kazuko
Department Of Biochemistry Tokyo Dental College : Oral Health Science Center Tokyo Dental College
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佐藤 裕
東京歯科大学生化学講座
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Ohta K
Department Of Agricultural Chemistry Faculty Of Agriculture Kyushu University
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Ohta K.
Department Of Biochemistry Tokyo Dental College
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Kizaki H
Department Of Biochemistry Tokyo Dental College
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Sato Yutaka
Department Of Biological Mechanisms And Functions Graduate School Of Bioagricultural Sciences Nagoya
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Wakabayashi M
Department Of Surgery Ikuta Hospital Shiga
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Sato Yutaka
Department Of Biochemistry And Oral Health Science Center Tokyo Dental College
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Okoshi R
Department of Biochemistry, Tokyo Dental College
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