Synthesis of 2α-Halo-4-en-3-oxo-steroids
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概要
- 論文の詳細を見る
Some 2-ethoxalyl-4-en-3-one was treated with N-halo-succinimide in pyridine to give the corresponding 2α-halo-4-en-3-one in a good yield. Direct chlorination of testosterone acetate with sulfuryl chloride (1 mole) gave a small amount of 2α-chlorotestosterone acetate in dry beozene or dry ether, and with sulfuryl chloride (excess) gave mainly 2α, 4-dichlorotestosterone acetate in dry benzene and mainly 2α, 6β-dichlorotestosterone acetate in dry ether. These observations were confirmed by the syntheses of their related compounds through the unequivocal routes.
- 社団法人日本薬学会の論文
- 1964-10-25
著者
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安田 喜久男
Research Laboratory, Teikoku Hormone Mfg. Co., Ltd.
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安田 喜久男
Research Division Teikoku Hormone Manufacturing Co. Ltd.
関連論文
- Further Preparation of Steroidal Diosphenols. I. Synthesis of Some 4,4-Dimethyl-2-hydroxy-3-oxo-1-ene Steroids in Androstane and Pregnane Series
- Synthesis of Some 3,5-Diene-2,7-dioxosteroids
- Studies on Agents with Vasodilator and β-Blocking Activities. III. Synthesis and Activity of Optical Isomers of TZC-1370
- Studies on Agents with Vasodilator and β-Blocking Activities. II
- Studies on Agents with Vasodilator and β-Blocking Activities. I
- Synthesis of 2α-Halo-4-en-3-oxo-steroids
- Long-range Effect of Halogen in the Nuclear Magnetic Resonance Spectra of Halosteroids
- Oxidation of 3-Enol Derivatives of 4-En-3-oxo-steroids by tert-Butyl Chromate.
- Preparation of Some Estriol Esters.