Pharmacokinetic Profile of Flavin Adenine Dinucleotide, Flavin Mononucleotide and Riboflavin Following Intravenous Administration of Riboflavin or Its Coenzymes in Rats

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概要

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• The pharmacokinetics and utilization (flavo-coenzyme formation) of an intravenously administered flavin mononucleotide (FMN) or riboflavin (RF) in rats were assessed using ethylenediamine-N,N,N',N'-tetraacetic acid (EDTA)-treated plasma. Serial blood samples were collected via a syringe containing EDTA, used to prevent flavin adenin dinucleotide (FAD) hydrolysis, from the left jugular vein and plasma samples were analyzed for FAD, FMN and RF levels using a reversed-phase HPLC method. After the intravenous bolus administration of a single dose of FMN (500nmol/kg), FAD was identified in plasma. However, increased levels of FAD in plasma were much less pronounced than that of RF levels. In contrast, after the intravenous bolus administration of single dose of RF (500nmol/kg), both FAD and FMN levels were not different from the endogenous levels. Evidence is given in this paper that intravenously administered FMN affects the plasma levels of FAD in rats, whereas insensible changes in FMN and FAD levels were not confirmed by intravenously administered RF. The plasma kinetics of total flavin after intravenous bolus administration of RF, FMN or FAD to rats was also estimated. Statistical analysis of individual data revealed a high correlation between the total flavin level obtained by summation of each flavin level and that obtained with the lumiflavin (LF) method. Since this method is highly sensitive, it could be used to give precise values for the pharmacokinetic parameters of flavins.

• 公益社団法人日本薬学会の論文
• 2007-06-01

著者

• Todo Hiroaki

  Faculty of Pharmaceutical Sciences, Josai University

• Sugibayashi Kenji

  Faculty of Pharmaceutical Sciences, Josai University

• Hayashi Teruaki

  Faculty Of Pharmaceutical Sciences Josai University

• HASEGAWA Tetsuya

  Faculty of Pharmaceutical Sciences, Josai University

• Hasegawa Tetsuya

  Faculty Of Pharmaceutical Sciences Josai International University

• AKIMOTO Masayuki

  Faculty of Pharmaceutical Sciences, Josai International University

• Sato Yuko

  Faculty of Pharmaceutical Science, Josai International University

• Nemoto Eiichi

  Faculty of Pharmaceutical Science, Josai International University

• Nemoto Eiichi

  Faculty Of Pharmaceutical Sciences Josai University:faculty Of Pharmaceutical Science Josai Internat

• Nemoto Eiichi

  Faculty Of Pharmaceutical Science Josai International University

• Sugibayashi Kenji

  Faculty Of Pharmaceutial Sciences Josai University

• Sugibayashi Kenji

  Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology

• Sugibayashi Kenji

  Fac. Of Pharmaceutical Sciences Josai Univ.

• Sugibayashi Kenji

  Josai-university Faculty Of Pharmaceutical Sciences

• Sugibayashi Kenji

  Department Of Neuropathology Tokyo Metropolitan Institute For Neurosciences

• Hasegawa Takaaki

  Faculty Of Engineering Saitama University

• Hayashi T

  Faculty Of Pharmaceutical Sciences Josai University

• Hasegawa Tetsuya

  Faculty Of Pharmaceutical Sciences Chiba University

• Hasegawa T

  Faculty Of Pharmaceutical Sciences Josai International University

• Sugibayashi K

  Faculty Of Pharmaceutical Sciences Josai University:life Science Research Center Josai University

• Todo Hiroaki

  Faculty Of Pharmaceutical Sciences Josai University

• Todo Hiroaki

  Faculty Of Pharmaceutical Science Josai University

• SUGIE Kenichi

  Josai-University faculty of pharmaceutical sciences

• Akimoto Masayuki

  Fac. Of Pharmaceutical Sciences Josai International Univ.

• Akimoto Masayuki

  Faculty Of Pharmaceutical Science Josai International University

• Sato Yuko

  Faculty Of Pharmaceutical Science Josai International University

• Hasegawa Tetsuya

  Faculty Of Pharmaceutical Science Josai International University

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