Involvement of 2-C-Methyl-D-erythritol-4-phosphate Pathway in Biosynthesis of Aphidicolin-Like Tetracyclic Diterpene of Scoparia dulcis
スポンサーリンク
概要
- 論文の詳細を見る
Specific inhibitors of the MVA pathway (pravastatin) and the MEP pathway (fosmidomycin) were used to interfere with the biosynthetic flux which leads to the production of aphidicolin-like diterpene in leaf organ cultures of Scoparia dulcis. Treatment of leaf organs with fosmidomycin resulted in dose dependent inhibition of chlorophylls, carotenoids, scopadulcic acid B (SDB) and phytol production, and no effect on sterol production was observed. In response to the pravastatin treatment, a significant decrease in sterol and pertubation of SDB production was observed.
- 2006-05-01
著者
-
Lee Jung-bum
富山大学 大学院医学薬学研究部
-
Lee Jung-bum
Faculty Of Pharmaceutical Sciences University Of Toyama
-
Lee J‐b
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical Uni
-
HAYASHI Toshimitsu
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
-
Hayashi Toshimitsu
Graduate School Of Medicine And Pharmaceutical Sciences For Res.
-
Hayashi Toshimitsu
Faculty Of Pharmaceutical Sciences University Of Toyama
-
Hayashi Toshimitsu
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
-
Hayashi Toshimitsu
Graduate School Of Medicine And Pharmaceutical Science For Research University Of Toyama
-
Hayashi T
Faculty Of Pharmaceutical Sciences Josai University
-
Hirooka Takashi
Organization For Frontier Research In Preventive Pharmaceutical Sciences Hokuriku University
-
NKEMBO Marguerite
Faculty of Pharmaceutical Sciences, University of Toyama
-
NAKAGIRI Takeshi
Faculty of Pharmaceutical Sciences, University of Toyama
-
Nakagiri Takeshi
Faculty Of Pharmaceutical Sciences University Of Toyama
-
Nkembo Marguerite
Faculty Of Pharmaceutical Sciences University Of Toyama
関連論文
- Characterization of Structures and Antiviral Effects of Polysaccharides from Portulaca oleracea L.
- Therapeutic Effect of Arctiin and Arctigenin in Immunocompetent and Immunocompromised Mice Infected with Influenza A Virus
- Phenoxazine Derivatives Suppress the Infections Caused by Herpes Simplex Virus Type-1 and Herpes Simplex Virus Type-2 Intravaginally Inoculated Into Mice
- Resistance of human brain microvascular endothelial cells in culture to methylmercury : cell-density-dependent defense mechanisms
- Suppression of fibroblast growth factor-2 expression : Possible mechanism underlying methylmercury-induced inhibition of the repair of wounded monolayers of cultured human brain microvascular endothelial cells
- Arsenite but not arsenate inhibits general proteoglycan synthesis in cultured arterial smooth muscle cells
- Homocysteine Inhibits Proteoglycan Synthesis in Cultured Bovine Aortic Smooth Muscle Cells
- Methylmercury Retards the Repair of Wounded Monolayer of Human Brain Microvascular Endothelial Cells by Inhibiting Their Proliferation without Nonspecific Cell Damage
- Proteoglycans Released from Cultured Bovine Aortic Endothelial Cell Layers by Sodium Spirulan Are Both Perlecan and Biglycan(Biochemistry/Molecular Biology)
- Stimulation of Proteoglycan Release from Cultured Vascular Endothelial Cell Layers by Sodium Spirulan
- Inhibition of the Association of Proteoglycans with Cultured Vascular Endothelial Cell Layers by Calcium and Sodium Spirulan
- Geranylgeranyl Diphosphate Synthase from Scoparia dulcis and Croton sublyratus. Plastid Localization and Conversion to a Farnesyl Diphosphate Synthase by Mutagenesis
- Involvement of 2-C-Methyl-D-erythritol-4-phosphate Pathway in Biosynthesis of Aphidicolin-Like Tetracyclic Diterpene of Scoparia dulcis
- Anti-herpes Simplex Virus Target of an Acidic Polysaccharide, Nostoflan, from the Edible Blue-Green Alga Nostoc flagelliforme(Pharmacognosy)
- Effect of l-Menthol-Ethanol-Water System on the Systemic Absorption of Flurbiprofen after Repeated Topical Applications in Rabbits
- Phenoxazine Derivatives Inactivate Human Cytomegalovirus, Herpes Simplex Virus-1, and Herpes Simplex Virus-2 In Vitro
- Isolation of Sulfated Galactan from Codium fragile and Its Antiviral Effect
- Antioxidant and Antiviral Activities of Plastoquinones from the Brown Alga Sargassum micracanthum, and a New Chromene Derivative Converted from the Plastoquinones(Pharmacognosy)
- STRUCTURE OF SCOPARIC ACID A, A NEW LABDANE-TYPE DITERPENOID FROM A PARAGUAYAN CRUDE DRUG "TYPYCHA KURATU" (SCOPARIA DULCIS L.)(Communications to the Editor)
- Cloning and Expression of Calmodulin Gene in Scoparia dulcis(Pharmacognosy)
- Antiviral Sulfated Polysaccharide from Navicula directa, a Diatom Collected from Deep-Sea Water in Toyama Bay(Pharmacognosy)
- Selective Enhancement of Scopadulcic Acid B Production in the Cultured Tissues of Scoparia dulcis by Methyl Jasmonate
- Stimulation of calcium signal transduction results in enhancement of production of scopadulcic acid B by methyl jasmonate in the cultured tissues of Scoparia dulcis
- Analysis of Skin Disposition and Metabolism of Ethyl Nicotinate after Topical Application Using Dual Agar Gel Disc-Inserted Rats(Biopharmacy)
- Analysis of Skin Disposition of Flurbiprofen after Topical Application Using Dual Agar Gel Discs-Inserted Rats(Biopharmacy)
- Pharmacokinetic Profile of Flavin Adenine Dinucleotide, Flavin Mononucleotide and Riboflavin Following Intravenous Administration of Riboflavin or Its Coenzymes in Rats
- Utility of a Three-Dimensional Cultured Human Skin Model as a Tool to Evaluate the Simultaneous Diffusion and Metabolism of Ethyl Nicotinate in Skin
- Skin Disposition of Drugs after Topical Application in Hairless Rats
- Effects of Plastoquinones from the Brown Alga Sargassum micracanthum and a New Chromene Derivative Converted from the Plastoquinones on Acute Gastric Lesions in Rats(Pharmacognosy)
- New Plastoquinones Isolated from the Brown Alga, Sargassum micracanthum
- Evaluation of Scopadulciol-Related Molecules for Their Stimulatory Effect on the Cytotoxicity of Acyclovir and Ganciclovir against Herpes Simplex Virus Type 1 Thymidine Kinase Gene-Transfected HeLa Cells
- Hydrolysis Rates of Olive Oil by Lipase in a Monodispersed O/W Emulsion System Using Membrane Emulsification
- Inhibition of Cultured Bovine Aortic Smooth Muscle Cell Proliferation by Colominic Acid(Pharmacology)
- Differential Effects of Sodium Spirulan on the Secretion of Fibrinolytic Proteins from Vascular Endothelial Cells : Enhancement of Plasminogen Activator Activity
- Novel Antiviral Fucoidan from Sporophyll of Undaria pinnatifida (Mekabu)
- A Novel Antivirally Active Fucan Sulfate Derived from an Edible Brown Alga, Sargassum horneri
- Effects of Structural Modification of Calcium Spirulan, a Sulfated Polysaccharide from Spirulina Platensis, on Antiviral Activity
- An Antivirally Active Sulfated Polysaccharide from Sargassum horneri (TURNER) C.AGARDH
- Geranylgeranyl Diphosphate Synthases from Scoparia dulcis and Croton sublyratus. cDNA Cloning, Functional Expression, and Conversion to a Farnesyl Diphosphate Synthase
- Inhibitory Activities of Plastoquinones and Chromene Derivative from a Brown Alga Sagassum micracanthum on Bone Resorption(Pharmacognosy)
- Antiviral Targets of a Chromene Derivative from Sargassum micracanthum in the Replication of Human Cytomegalovirus(Microbiology)
- Conversion of FAD to FMN and Riboflavin in Plasma : Effects of Measuring Method(Biopharmacy)
- Antiviral and Immunostimulating Effects of Lignin-Carbohydrate-Protein Complexes from Pimpinella anisum
- Cloning and Characterization of Sdga Gene Encoding α-Subunit of Heterotrimeric Guanosine 5'-Triphosphate-Binding Protein Complex in Scoparia dulcis(Pharmacognosy)
- P-206 SYNERGISTIC EFFECT OF OSELTAMIVIR AND ARCTIGENIN FROM SEEDS (GOBOSHI) OF ARCTIUM LAPPA L. ON ANTI-INFLUENZA A VIRUS ACTIVITY
- Seed Germination and Diterpenoid Production in Seedlings of Scoparia dulcis L
- Evaluation of an Edible Blue-Green Alga, Aphanothece sacrum, for Its Inhibitory Effect on Replication of Herpes Simplex Virus Type 2 and Influenza Virus Type A
- In Vitro Characterization of the Cytochrome P450 Isoforms Involved in the Metabolism of 6-Methoxy-2-napthylacetic Acid, an Active Metabolite of the Prodrug Nabumetone
- Two new monoterpenes from Sibiraea angustata
- Antiviral and Immunostimulating Effects of Lignin-Carbohydrate-Protein Complexes from Pimpinella anisum
- Stimulation of calcium signal transduction results in enhancement of production of scopadulcic acid B by methyl jasmonate in the cultured tissues of Scoparia dulcis
- Seed Germination and Diterpenoid Production in Seedlings of Scoparia dulcis L.
- Phenoxazine Derivatives Suppress the Infections Caused by Herpes Simplex Virus Type-1 and Herpes Simplex Virus Type-2 Intravaginally Inoculated Into Mice
- Potent virucidal effect of pheophorbide a and pyropheophorbide a on enveloped viruses
- Studies on Muscle Relaxants in Paeoniae Radix. : Effect of Heat on Stability of Paeoniflorigenone
- Constituents of Liquidamber formosana (Hamamelidaceae)
- Isolation and Identification of Cytotoxic Principles from Chrysosplenium japonicum MAXIM. (Saxifragaceae)
- Anti-Influenza Virus Effects of Elderberry Juice and Its Fractions
- Chemical and Pharmaceutical Studies on Medicinal Plants in Paraguay : Constituents of Angiotensin Converting Enzyme Inhibitory Fraction from "Cocu," Allophylus edulis RADLK