Therapeutic Effect of Arctiin and Arctigenin in Immunocompetent and Immunocompromised Mice Infected with Influenza A Virus
スポンサーリンク
概要
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Arctiin and its aglucone, arctigenin from the fruits of Arctium lappa L. showed potent in vitro antiviral activities against influenza A virus (A/NWS/33, H1N1) (IFV). Based on the data from time-of-addition experiments and on release tests of progeny viruses, arctigenin was assumed to interfere with early event(s) of viral replication after viral penetration into cells, and to suppress the release of progeny viruses from the host cells. Arctiin was orally effective against either IFV-inoculated normal or 5-fluorouracil (5-FU)-treated mice, being less effective as compared with oseltamivir. Noticeably, arctiin produced a larger amount of virus-specific antibody than those of control and oseltamivir in sera collected from 5-FU-treated mice. Furthermore, oral treatment of 5-FU-treated mice with arctiin did not induce any resistant viruses, although the same treatment with oseltamivir induced resistant viruses at a 50% frequency. When the combination of arctiin and oseltamivir was administered to normal mice infected with IFV, the virus yields in both bronchoalveolar lavage fluids and lungs were significantly reduced relative to those in the mice treated with arctiin or oseltamivir alone. Thus, monotherapy of arctiin or combined therapy of arctiin with oseltamivir would be another treatment option for influenza.
著者
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Hayashi Kyoko
Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Japan
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Hayashi Toshimitsu
Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Japan
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UESATO Shinichi
Department of Biotechnology, Faculty of Engineering, Kansai University
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NAGAOKA Yasuo
Department of Biotechnology, Faculty of Engineering, Kansai University
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Hayashi K
School Of Medicine Toyama Medical And Pharmaceutical University
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Hayashi Toshimitsu
Graduate School Of Medicine And Pharmaceutical Science For Research University Of Toyama
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Nagaoka Yasuo
Department Of Biotechnology Faculty Of Engineering Kansai Univeristy
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Uesato Shinichi
Department Of Biotechnology Faculty Of Engineering Kansai Univeristy
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Narutaki Kazuto
Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Engineering, Kansa
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Nagaoka Yasuo
Department Of Life Science And Biotechnology Faculty Of Chemistry Material And Bioengineering Kansai
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Nagaoka Yasuo
Fac. Of Chemistry Materials And Bioengineering Kansai Univ.
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Hayashi Kyoko
Graduate School Of Medicine And Pharmaceutical Sciences For Research University Of Toyama
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Uesato Shinichi
Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Engineering, Kansai University
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Nagaoka Yasuo
Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Engineering, Kansai University
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Narutaki Kazuto
Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Engineering, Kansai University
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