N-Substituted Hydroxyureas as Urease Inhibitors
スポンサーリンク
概要
- 論文の詳細を見る
In order to seek a urease inhibitor more potent than hydroxyurea (1), its alkyl- or phenyl-substituted derivatives were synthesized and evaluated for their effect on the jack bean urease. Of 16 compounds tested, m-methyl-(10) and m-methoxy-phenyl substituted hydroxyurea (13) showed the most potent inhibitory activities against the enzyme.
- 公益社団法人日本薬学会の論文
- 2002-09-01
著者
-
KUWAJIMA Hiroshi
Faculty of Pharmaceutical Sciences, Kinki University
-
UESATO Shinichi
Department of Biotechnology, Faculty of Engineering, Kansai University
-
NAGAOKA Yasuo
Department of Biotechnology, Faculty of Engineering, Kansai University
-
Kuwajima Hiroshi
Faculty Of Pharmaceutical Sciences Kinki University
-
Nagaoka Yasuo
Department Of Biotechnology Faculty Of Engineering Kansai Univeristy
-
Uesato Shinichi
Department Of Biotechnology Faculty Of Engineering Kansai Univeristy
-
HASHIMOTO Yuichiro
Department of Biotechnology, Faculty of Engineering, Kansai Univeristy
-
NISHINO Masaru
Department of Biotechnology, Faculty of Engineering, Kansai Univeristy
-
Nishino Masaru
Department Of Biotechnology Faculty Of Engineering Kansai Univeristy
-
Hashimoto Yuichiro
Department Of Biotechnology Faculty Of Engineering Kansai Univeristy
関連論文
- Therapeutic Effect of Arctiin and Arctigenin in Immunocompetent and Immunocompromised Mice Infected with Influenza A Virus
- Glycosides of Benzyl and Salicyl Alcohols from Alangium chinense
- A Tetrahydroisoquinoline-monoterpene Glucoside and an Iridoid Glucoside from Alangium kurzii
- Inhibitory Effects of 3-O-Acyl-(+)-catechins on Epstein-Barr Virus Activation
- Comparative Examination of Anti-proliferative Activities of (-)-Epigallocatechin Gallate and (-)-Epigallocatechin against HCT116 Colorectal Carcinoma Cells(Pharmacognosy)
- Inhibitory Effects of Cancer Cell Proliferation by Novel Histone Deacetylase Inhibitors Involve p21/WAF1 Induction and G_2/M Arrest(Medicinal Chemistry)
- BUILDING AN INTERNATIONAL NETWORK EXCHANGE PROGRAM OF EDUCATION AND RESEARCH FOR GRADUATE COURSE STUDENTS IN LIFE SCIENCE AND BIOTECHNOLOGY(LIFE SCIENCE AND BIOTECHNOLOGY,50th anniversary edition)
- Effects of a Novel Histone Deacetylase Inhibitor, N-(2-Aminophenyl) Benzamide, on a Reversible Hypertrophy Induced by Isoproterenol in In Situ Rat Hearts
- Tumor Chemopreventive Effect of Orally Administered (-)-Epigallocatechin and Its 3-O-Acylated Derivatives on the Two Stage Mouse Skin Carcinogenesis Induced by Peroxynitrite and 12-O-Tetradecanoylphorbol-13-acetate
- Antiproliferative Activity of Some Catechins against Her2/neu-Overexpressing Human Breast Carcinoma SKBR3
- Inhibitory Effect of (−)-Epigallocatechin and (−)-Epigallocatechin Gallate against Heregulin β1-Induced Migration/Invasion of the MCF-7 Breast Carcinoma Cell Line
- Growth Inhibition of Human Colon Cancer Cell Line HCT116 by Bis[2-(acylamino)phenyl] Disulfide and Its Action Mechanism(Pharmacognosy)
- P-206 SYNERGISTIC EFFECT OF OSELTAMIVIR AND ARCTIGENIN FROM SEEDS (GOBOSHI) OF ARCTIUM LAPPA L. ON ANTI-INFLUENZA A VIRUS ACTIVITY
- Conformational Analysis of Febrifugines and Halofuginones in Organic Solvents
- Purification, Characterization, and Overexpression of Psychrophilic and Thermolabile Malate Dehydrogenase of a Novel Antarctic Psychrotolerant, Flavobacterium frigidimaris KUC-1
- Stereoselective Conversion of Anhydrovinblastine into Vinblastine Utilizing an Anti-vinblastine Monoclonal Antibody as a Chiral Mould
- Cicadapeptins from a Fungus Isaria sinclairii Inhibit Acetylcholine-Evoked Secretion of Catecholamines from Bovine Adrenal Chromaffin Cells
- STRUCTURE-ACTIVITY RELATIONSHIPS OF ANTIBIOTIC PEPTIDES WHICH CAUSE Ca^-DEPENDENT CATECHOLAMINE RELEASE
- ISOLATION AND STRUCTURE-ACTIVITY RELATIONSHIPS OF ANTIBIOTIC PEPTIDES, TRICHOSPORIN-Bs, WHICH CAUSE Ca^-DEPENDENT CATECHOLAMINE RELEASE FROM ADRENAL MEDULLARY CHROMAFFIN CELLS
- Synthesis of ^C-Labeled Possible Intermediates in the Biosynthesis of Phenylethanoid Derivatives, Cornoside and Rengyosides
- Antioxidative Activity of 3-O-Octanoyl-(+)-Catechin, a Newly Synthesized Catechin, in Vitro
- N-Substituted Hydroxyureas as Urease Inhibitors
- Copper(II) Ions Convert Catechins from Antioxidants to Prooxidants in Protein Carbonyl Formation
- Biosynthesis of Oleoside-, 10-Hydroxyoleoside- and Ligustaloside-Type Glucosides from Secologanin
- Synthesis of Four Possible Intermediates after Secologanin on the Biosynthesis of the Oleoside-, 10-Hydroxyoleoside- and Ligustaloside-Type Glucosides in Oleaceous Plants
- Tumor Chemopreventive Effect of Orally Administered (-)-Epigallocatechin and Its 3-O-Acylated Derivatives on the Two Stage Mouse Skin Carcinogenesis Induced by Peroxynitrite and 12-O-Tetradecanoylphorbol-13-acetate
- Antiproliferative Activity of Some Catechins against Her2/neu-Overexpressing Human Breast Carcinoma SKBR3
- The formation of trapped electrons upon the thermal dehydration-condensation of hydrated hydrogenorthophosphates.