Inhibitory Effect of (−)-Epigallocatechin and (−)-Epigallocatechin Gallate against Heregulin β1-Induced Migration/Invasion of the MCF-7 Breast Carcinoma Cell Line

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概要

• 論文の詳細を見る

• Migration/invasion is involved in the multiple steps of metastasis, resulting in a poor prognosis of breast cancer. (−)-Epigallocatechin-3-gallate (EGCG) in green tea inhibits the metastasis of some cancer cell lines. Cell migration/invasion assays using Boyden chambers demonstrated that (−)-epigallocatechin (EGC), another green tea catechin, inhibited heregulin-β1 (HRG)-induced migration/invasion of MCF-7 human breast carcinoma cells to approximately the same extent as EGCG. Assays of cytoskeletal reorganization, Western blotting and immunoprecipitation suggested that EGCG inhibited this migration/invasion by suppressing the HRG-stimulated activation of epidermal growth factor receptor-related protein B2 (ErbB2)/ErbB3/protein kinase B (Akt), whereas EGC did so through pathways including the disruption of the HRG-stimulated activation of ErbB2/ErbB3 but not Akt. EGC, as well as EGCG, could play an important role against the promotion of metastasis of breast cancer cells.

• 日本薬学会の論文

著者

• Kushima Yukihiro

  関西大学 化学生命工学部生命･生物工学

• Baba Kimiye

  Osaka Univ. Pharmaceutical Sci. Osaka Jpn

• UESATO Shinichi

  Department of Biotechnology, Faculty of Engineering, Kansai University

• NAGAOKA Yasuo

  Department of Biotechnology, Faculty of Engineering, Kansai University

• Sakaguchi Minoru

  Osaka University Of Pharmaceutical Sciences

• KUSHIMA Yukihiro

  Department of Life Science and Biotechnology, Faculty of Chemistry, Material and Bioengineering, Kan

• IIDA KAZUKI

  Department of Pediatrics, School of Medicine, Sapporo Medical University

• Iida Kazuki

  Department Of Bioscience National Cardiovascular Center

• Nagaoka Yasuo

  Department Of Biotechnology Faculty Of Engineering Kansai Univeristy

• Uesato Shinichi

  Department Of Biotechnology Faculty Of Engineering Kansai Univeristy

• Sakaguchi Minoru

  Osaka University

• Kawaratani Yasuyuki

  Department of Life Science and Biotechnology, Faculty of Chemistry, Material and Bioengineering, Kan

• Shirahama Tatsuya

  Department of Life Science and Biotechnology, Faculty of Chemistry, Material and Bioengineering, Kan

• Hara Yukihiko

  Polyphenon Division, Mitsui Norin Co., Ltd.

• Shirahama Tatsuya

  Department Of Biotechnology Faculty Of Engineering Kansai University

• Nagaoka Yasuo

  Department Of Life Science And Biotechnology Faculty Of Chemistry Material And Bioengineering Kansai

• Kawaratani Yasuyuki

  Department Of Life Science And Biotechnology Faculty Of Chemistry Material And Bioengineering Kansai

• Nagaoka Yasuo

  Fac. Of Chemistry Materials And Bioengineering Kansai Univ.

• Iida Kazuki

  Department of Life Science and Biotechnology, Faculty of Chemistry, Material and Bioengineering, Kansai University

• Nagaoka Yasuo

  Department of Life Science and Biotechnology, Faculty of Chemistry, Material and Bioengineering, Kansai University

• Shirahama Tatsuya

  Department of Life Science and Biotechnology, Faculty of Chemistry, Material and Bioengineering, Kansai University

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