Inhibitory Effects of Cancer Cell Proliferation by Novel Histone Deacetylase Inhibitors Involve p21/WAF1 Induction and G_2/M Arrest(Medicinal Chemistry)
スポンサーリンク
概要
- 論文の詳細を見る
Two compounds were synthesized which have a structural component other than those of our new series histone deacetylase (HDAC) inhibitors to determine the structure-activity relationship. It was also examined whether the inhibitory effects on cancer cell proliferation by HDAC inhibitors involve p21/WAF1 induction and G_1 or G_2/M arrest in p53-mutated MG63 human osteosarcoma cells as do other HDAC inhibitors. It was demonstrated that inhibitors with the 2-naphthylcarbonyl group and hydroxamic acid at both termimal sides as well as the phenylene component at the center of molecule markedly induce the p21/WAF1 protein by stimulating p21/WAF1 gene promoter activity. Furthermore, cell cycle analysis revealed that these compounds arrest MG63 cells in the G_2/M phase.
- 2005-05-01
著者
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Sakai Toshiyuki
Department Of Hospital Pharmacy School Of Medicine Kobe University
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UESATO Shinichi
Department of Biotechnology, Faculty of Engineering, Kansai University
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NAGAOKA Yasuo
Department of Biotechnology, Faculty of Engineering, Kansai University
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SOWA Yoshihiro
Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefe
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TAKAGAKI Nobumasa
Department of Internal Medicine, Daini Okamoto Hospital
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YOGOSAWA Shingo
Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefe
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Nagaoka Yasuo
Department Of Biotechnology Faculty Of Engineering Kansai Univeristy
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Uesato S
Department Of Life Science And Biotechnology Faculty Of Chemistry Material And Bioengineering Kansai
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Uesato Shinichi
Department Of Biotechnology Faculty Of Engineering Kansai Univeristy
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MAEDA Taishi
Department of Biotechnology, faculty of Engineering, Kansai University
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Nagaoka Y
Kansai Univ. Osaka Jpn
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Sowa Yoshihiro
Department Of Molecular-targeting Cancer Prevention Graduate School Of Medical Science Kyoto Prefect
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Sowa Yoshihiro
Department Of Molecular-targeting Cancer Prevention Department Of Medicine Graduate School Of Medica
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KAWAI Yuki
Department of Biotechnology, Faculty of Engineering, Kansai University
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YASUDA Chikako
Department of Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine, Gradu
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Kawai Yuki
Department Of Biotechnology Faculty Of Engineering Kansai University
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Yasuda Chikako
Department Of Molecular-targeting Cancer Prevention Kyoto Prefectural University Of Medicine Graduat
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Maeda Taishi
Department Of Biotechnology Faculty Of Engineering Kansai University
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Uesato S
Dep. Of Life Sci. And Biotechnology Fac. Of Chemistry Materials And Engineering Kansai Univ.
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Yogosawa Shingo
Department Of Molecular-targeting Cancer Prevention Graduate School Of Medical Science Kyoto Prefect
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Takagaki Nobumasa
Department Of Internal Medicine Daini Okamoto Hospital
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Takagaki Nobumasa
Department Of Molecular-targeting Cancer Prevention Kyoto Prefectural University Of Medicine Graduat
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Nagaoka Yasuo
Department Of Biotechnology Faculty Of Engineering Kansai University:high Technology Research Center
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Nagaoka Yasuo
Department Of Life Science And Biotechnology Faculty Of Chemistry Material And Bioengineering Kansai
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Sakai Toshiyuki
Department Of Molecular-targeting Cancer Prevention Graduate School Of Medical Science Kyoto Prefect
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Nagaoka Yasuo
Fac. Of Chemistry Materials And Bioengineering Kansai Univ.
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