Effect of Rabeprazole on MDR1-Mediated Transport of Rhodamine 123 in Caco-2 and Hvr100-6 Cells(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
The aim of our study was to investigate the effects of rabeprazole, a proton pump inhibitor, on MDR1 expressed on human colon carcinoma cell line, Caco-2, and MDR1-overexpressing human cervical carcinoma cell line, HeLa cells selected by exposure to 100nM vinblastine (Hvr100-6 cells). Inhibitory effects of rabeprazole on MDR1-mediated transport of Rhodamine123 were examined in these cells. A thousand micro molar rabeprazole increased Rhodamine 123 uptakes in Caco-2 and Hvr100-6 cells by 68% and 185%, respectively. No significant effects of rabeprazole were observed at the concentration of 1-100μM. Since rabeprazole did not show any effects on Rhodamine 123 transport via MDR1 at the plasma levels (approximately 1 μM), it was considered that the drug interaction with MDR1 substrates would be minimal even though the interaction occurred in the patients with rabeprazole treatment.
- 社団法人日本薬学会の論文
- 2004-10-01
著者
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SAKAEDA Toshiyuki
Department of Hospital Pharmacy, Kobe University School of Medicine
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大西 憲明
京都薬科大学臨床薬学教育研究センター
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Ohnishi N
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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Yoshida Kentaro
筑波大学 循環器内科
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Yoshida Kentarou
東京女子医科大学 循環器内科学
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Sakai Toshiyuki
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Kimura T
Kobe University Graduate School Of Medicine
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Kobayashi H
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Hirai M
Kobe Pharmaceutical University
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Kobayashi Hironao
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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Takara Kohji
Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University
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HOMMA Masato
Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University o
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ITAGAKI Fumio
Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University o
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KOHDA Yukinao
Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University o
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OHNISHI Noriaki
Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University
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YOKOYAMA Teruyoshi
Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University
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YAGAMI Tatsurou
Shionogi Research Laboratories, Shionogi & Co., Ltd.
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OKAMURA Noboru
Shionogi Research Laboratories, Shionogi & Co., Ltd.
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Takara Kohji
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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Takara Kohji
Department Of Clinical Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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Takara Kohji
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Ohmoto Nobuko
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Okamura N
Department Of Clinical Evaluation Of Pharmacotherapy Kobe University Graduate School Of Medicine
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Okamura Noboru
School Of Allied Health Sciences Tokyo Medical And Dental University
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Sakaeda Toshiyuki
Department Of Hospital Pharmacy Kobe University Hospital
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Shirakawa T
Kobe University School Of Medicine
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Shirakawa Toshiro
Department Of Urology Kobe University School Of Medicine
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Yagami Tatsurou
2shionogi Research Laboratories Shionogi & Co. Ltd.
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Homma M
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Homma Masato
Department Of Clinical Pharmacology Institute Of Cliniical Medicine University Of Tsukuba
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Itagaki Fumio
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Yokoyama T
Kitasato Univ. Sagamihara Jpn
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Yokoyama T
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Yokoyama Teruyoshi
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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Horinouhi Masanori
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Kohda Yukinao
Department Of Pharmacy Tsukuba University Hospital:department Of Pharmaceutical Sciences Graduate Sc
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Kohda Yukinao
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Ohnishi Noriaki
Department Of Applied Fine Chemistry Faculty Of Engineering Osaka University
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Kobayashi Hironao
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Kohda Y
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Sakai T
Department Of Internal Medicine And Gastrointestinal Endoscopy Saga Medical School
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Homma Masato
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Okamura N
Shionogi & Co. Ltd. Toyonaka Jpn
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Koishi Tomokazu
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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Yagami Tatsurou
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Kohda Yukinao
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Kohda Yukinao
Department Of Cardiology University Of Tsukuba Graduate School Of Comprehensive Human Sciences
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