Inhibitory Effects of Ticlopidine and Dilazep on Serum-Induced DNA Synthesis in Cultured Rat Renal Mesangial Cells
スポンサーリンク
概要
- 論文の詳細を見る
The effect of two anti-platelet drugs, ticlopidine and dilazep, on the fetal bovine serum (FBS)-induced DNA synthesis of cultured rat renal mesangial cells was assessed by means of an [3^H] thymidine incorporation assay. Each drug inhibited the 2% FBS-induced [^3H] thymidine incorporation in a concentration-dependent manner, similar to the inhibition of dipyridamole. The [^3H] thymidine incorporation was significantly suppressed by the treatment of more than 1μM ticlopidine or dilazep. It was thus suggested that ticlopidine and dilazep, might prevent the progression of such glomerular diseases as proliferative glomerulonephritis, at least in part, by suppressing mesangial cell proliferation.
- 日本医療薬学会の論文
- 1998-02-10
著者
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Ohnishi N
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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OHNISHI Noriaki
Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University
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YOKOYAMA Teruyoshi
Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University
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Yagami Tatsurou
2shionogi Research Laboratories Shionogi & Co. Ltd.
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NAGASAWA Kazuki
Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University
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Yokoyama T
Kitasato Univ. Sagamihara Jpn
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Yokoyama T
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Yokoyama Teruyoshi
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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Ohnishi Noriaki
Department Of Applied Fine Chemistry Faculty Of Engineering Osaka University
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NOMIYAMA MASAKO
Department of Hospital Pharmacy, Kyoto Pharmaceutical University
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Nagasawa Kazuki
Institute Of Molecular And Cellular Biosciences The University Of Tokyo
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Nagasawa Kazuki
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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Nagasawa Kazuki
Department Of Environmental Biochemistry Kyoto Pharmaceutical University
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Nomiyama Masako
Department Of Hospital Pharmacy Kyoto Pharmaceutical University
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