Transport Mechanism of Anthracycline Derivatives in Human Leukemia Cell Lines : Uptake and Efflux of Daunorubicin and Doxorubicin in HL60 and Its Resistant Cells and Comparison with Those of Pirarubicin
スポンサーリンク
概要
- 論文の詳細を見る
We examined the transport mechanisms of daunorubicin (DNR) and doxorubicin (ADR) in HL60 and HL60/THP cells which were the non-P-glycoprotein-mediated resistant clone of the parent HL60 cells and showed a low degree of resistance, and compared them with those of pirarubicin (THP). In both lines, it appeared that the uptakes of DNR and ADR were time-, temperature- and concentration-dependent and energy independent, and the transport of DNR consisted of saturable and nonsaturable components. They were pumped out from the cells time-, temperature- and energy-dependently. There were no differences in the accumulation amount of either DNR or ADR between HL60 and HL60/THP cells. Comparing the transport of DNR or ADR with that of THP, the uptake amounts of DNR and THP were approximately equal, and were greater than that of ADR in both types of cell. In cis-inhibition experiments, DNR inhibited the THP uptake noncompetitively in the parent and resistant cells, in contradiction of the previously reported result in which ADR showed competitive inhibition (Nagasawa, K. et al., Cancer Chemother. Pharmacol., in press). The THP accumulation appeared to be increased by preload of DNR and ADR, indicating a counter transport. Thus, DNR and ADR as well as THP might be incorporated via a common carrier-mediated transport system, but DNR uptake in part appeared to follow a nonsaturable transport, and its binding site in the carrier might differ from that of THP and ADR in both HL60 and HL60/THP cells.
- 公益社団法人日本薬学会の論文
- 1996-01-15
著者
-
Ohnishi N
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
-
OHNISHI Noriaki
Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University
-
YOKOYAMA Teruyoshi
Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University
-
Yagami Tatsurou
2shionogi Research Laboratories Shionogi & Co. Ltd.
-
NAGASAWA Kazuki
Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University
-
Yokoyama T
Kitasato Univ. Sagamihara Jpn
-
Yokoyama Teruyoshi
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
-
Ohnishi Noriaki
Department Of Applied Fine Chemistry Faculty Of Engineering Osaka University
-
NOMIYAMA MASAKO
Department of Hospital Pharmacy, Kyoto Pharmaceutical University
-
NATAZUKA Toshiki
Hematology
-
NOMIYAMA Masako
Oncology Division, Department of Medicine and Hyogo Institute of Clinical Research, Hyogo Medical Ce
-
Nagasawa Kazuki
Institute Of Molecular And Cellular Biosciences The University Of Tokyo
-
Nagasawa Kazuki
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
-
Nagasawa Kazuki
Department Of Environmental Biochemistry Kyoto Pharmaceutical University
-
Nomiyama Masako
Department Of Hospital Pharmacy Kyoto Pharmaceutical University
関連論文
- ベトナム人脊髄性筋萎縮症患者におけるSMN2遺伝子量ならびにNAIP遺伝子量について
- Deletion of the SMN1 and NAIP Genes in Vietnamese Patients with Spinal Muscular Atrophy
- Effects of 19 Herbal Extracts on the Sensitivity to Paclitaxel or 5-Fluorouracil in HeLa Cells(Biopharmacy)
- Three-Dimensional, but not Two-Dimensional, Culture Results in Tumor Growth Enhancement after Exposure to Anticancer Drugs
- MDR1 Gene Polymorphism in Japanese Patients with Schizophrenia and Mood Disorders Including Depression(Biopharmacy)
- Effect of Rabeprazole on MDR1-Mediated Transport of Rhodamine 123 in Caco-2 and Hvr100-6 Cells(Biopharmacy)
- Effects of Reactive Oxygen Species on Cell Proliferation and Death in HeLa Cells and Its MDR1-Overexpressing Derivative Cell Line
- Effects of carvedilol on MDR1-mediated multidrug resistance : comparison with verapamil
- Effects of St John's Wort and Hypericin on Cytotoxicity of Anticancer Drugs
- Cytotoxic Effects of 27 Anticancer Drugs in HeLa and MDR1-Overexpressing Derivative Cell Lines
- Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma
- Studies on Interactions between Functional Foods or Dietary Supplements and Medicines. III. Effects of Ginkgo biloba Leaf Extract on the Pharmacokinetics of Nifedipine in Rats(Biopharmacy)
- Studies on Interactions between Functional Foods or Dietary Supplements and Medicines. I. Effects of Ginkgo biloba Leaf Extract on the Pharmacokinetics of Diltiazem in Rats(Biopharmacy)
- Studies on Interactions between Traditional Herbal and Western Medicines.V. Effects of Sho-saiko-to (Xiao-Cai-hu-Tang) on the Pharmacokinetics of Carbamazepine in Rats
- Studies on interactions between traditional herbal and Western medicines. III. Effects of Sho-seiryu-to (Tin Chuan Tang) on the pharmacokinetics of phenytoin in rats
- A Strong Exonic Splicing Enhancer in Dystrophin Exon 19 Achieve Proper Splicing Without an Upstream Polypyrimidine Tract
- Tandem duplications of two separate fragments of the dystrophin gene in a patient with Duchenne muscular dystrophy
- Mutation Analysis of the Ornithine Transcarbamylase (OTC) Gene in Five Japanese OTC Deficiency Patients Revealed Two Known and Three Novel Mutations Including a Deep Intronic Mutation
- Mosaic Tetrasomy 9p Case with the Phenotype Mimicking Klinefelter Syndrome and Hyporesponse of Gonadotropin-Stimulated Testosterone Production
- Nobel cryptic exons identified in introns 2 and 3 of the human dystrophin gene with duplication of exons 8-11
- Use of Sample Hematocrit Value to Correct Blood Tacrolimus Concentration Derived by Microparticle Enzyme Immunoassay(Highlighted paper selected by Editor-in-chief,Miscellaneous)
- Studies on Interactions between Functional Foods or Dietary Supplements and Medicines. IV. Effects of Ginkgo biloba Leaf Extract on the Pharmacokinetics and Pharmacodynamics of Nifedipine in Healthy Volunteers(Biopharmacy)
- Up-Regulation of MDR1 Function and Expression by Cisplatin in LLC-PK_1 Cells
- Contribution of the Nucleoside Transport System to Doxorubicin Transport in HL60 Cells but Not in Mononuclear Cells
- Membrane Transport and Antitumor Activity of Pirarubicin, and Comparison with Those of Doxorubicin
- Studies on Interactions between Traditional Herbal and Western Medicines. I. Effects of Sho-seiryu-to on the Pharmacokinetics of Carbamazepine in Rats
- Possibility of Contribution of Nucleoside Transport Systems to Pirarubicin Uptake by HL60 Cells but Not Mononuclear Cells
- Inhibitory Effects of Ticlopidine and Dilazep on Serum-Induced DNA Synthesis in Cultured Rat Renal Mesangial Cells
- Pharmacokinetic Interaction between Theophylline and Propentofylline in Rats
- Transport Mechanism of Pirarubicin in Human Mononuclear Cells
- Transport Mechanisms of Anthracycline Derivatives in Human Leukemia Cell Lines : Uptake of Pirarubicin, Daunorubicin and Doxorubicin by K562 and Multidrug-Resistant K562/ADM Cell
- Transport Mechanism of Anthracycline Derivatives in Human Leukemia Cell Lines : Uptake and Efflux of Daunorubicin and Doxorubicin in HL60 and Its Resistant Cells and Comparison with Those of Pirarubicin
- Pharmacokinetics of Pirarubicin in Pediatric Patients
- Conversion of Ca^ Salt of an Organic Compound to Its Li^+ Salt to Simplify the Fast Atom Bombardment Mass Spectrum
- Coordination of Sodium Cation to an Oxygen Function and Olefinic Double Bond to Form Molecular Adduct Ion in Fast Atom Bombardment Mass Spectrometry
- Effect of Clarithromycin on the Bioavailability of Cyclosporin in Rats
- Pharmacokinetics of Zonisamide ; Saturable Distribution into Human and Rat Erythrocytes and into Rat Brain
- Molecular and Pharmacokinetic Properties of 222 Commercially Available Oral Drugs in Humans
- Activation of C-Kinase η through Its Cholesterol-3-sulfate-Dependent Phosphorylation by Casein Kinase I in Vitro(Biochemistry/Molecular Biology)
- Characterization of (-)-Matairesinol as a Potent Inhibitor of Casein Kinase I in Vitro
- Development of Novel Chiral Urea Catalysts for the Hetero-Michael Reaction
- Specific Nonpeptide Inhibitors of Puromycin-Sensitive Aminopeptidase with a 2,4(1H,3H)-Quinazolinedione Skeleton
- Cyclooxygenase Inhibitors Derived from Thalidomide
- Intraperitoneal administration of phosphorothioate antisense oligodeoxynucleotide against splicing enhancer sequence induced exon skipping in dystrophin mRNA expressed in mdx skeletal muscle
- Enhancing Effect of an Acetone Extract of Zingiberis rhizoma on Rectal Absorption of Mefenamic Acid in Rats
- Interactions between medicines and functional foods or dietary supplements
- Altered Levels of Oxidation and Phospholipase C Isozyme Expression in the Brains of Theanine-Administered Rats(Molecular and Cell Biology)
- Decreased Expression of Phospholipase C-β1 Protein in Endoplasmic Reticulum Stress-Loaded Neurons(Biochemistry)
- Mouse Equilibrative Nucleoside Transporter 2 (mENT2) Transports Nucleosides and Purine Nucleobases Differing from Human and Rat ENT2(Molecular and Cell Biology)
- Effect of Phosphotyrosine Proteins on Phorbol Myristate Acetate-Induced NADPH Oxidase Activation in Guinea Pig Peritoneal Polymorphonuclear Leukocytes
- Alterations of Phospholipase C Isozymes in Rat Cerebral Cortex through Hyperoxia
- Laser Properties of Nonlinear Optical Benzal Barbituric Acid Crystals
- Ticlopidine Inhibits Activation of Mitogen-Activated Protein Kinase by Platelet-Derived Growth Factor in Cultured Rat Renal Mesangial Cells
- Transport Mechanisms of Idarubicin, an Anthracycline Derivative, in Human Leukemia HL60 Cells and Mononuclear Cells, and Comparison with Those of Its Analogs
- Interactions between functional foods and drugs (WORKSHOP2: EFFECTS OF FOODS ON DRUG EFFECTS) (Proceedings of the 30th Annual Meeting)