Studies on Interactions between Traditional Herbal and Western Medicines. I. Effects of Sho-seiryu-to on the Pharmacokinetics of Carbamazepine in Rats

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The effects of oral co- and pre-administration of Sho-seiryu-to extract powder (TJ-19,1 g/kg), a widely used Kampo (traditional Chinese herbal) medicine, on the pharmacokinetics of an anti-epileptic drug, carbamazepine(CBZ), and its active metabolite (carbamazepine-10,11-epoxide, CBZ-E) after oral administration of CBZ(50 mg/kg) were examined in male rats. The simultaneous administration of TJ-19 significantly lengthened the time to reach the peak plasma concentration (T_<max>), but did not influence the peak plasma concentration, area under the plasma concentration-time curve or terminal elimination half-life (t_<1/2>). Each parameter for CBZ or CBZ-E with a single pretreatment with TJ-19 was not significantly different from that with the vehicle. T_<max> and the elimination rate constant for CBZ were significantly increased by 1-week repeated pretreatment with TJ-19,by 83% (p<0.01) and 88% (p<0.001), respectively.t_<1/2> and the mean residence time from zero to infinity (MRT_<0-∞>)in the TJ-19 pretreatment group were significantly shortened, by 52 and 34% (p<0.005), respectively. No significant difference in the bound fraction of each drug at two concentrations (1 and 10 μg/ml) was observed between the control and TJ-19 pretreatment groups. These results indicate that simultaneous oral administration of TJ-19 delays the oral absorption of CBZ, while 1-week repeated pretreatment with TJ-19 accelerates the metabolism of CBZ in rats, without affecting the protein binding of CBZ.
公益社団法人日本薬学会の論文
1999-05-15

Studies on Interactions between Traditional Herbal and Western Medicines. I. Effects of Sho-seiryu-to on the Pharmacokinetics of Carbamazepine in Rats

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