Analysis of Current State Regarding the Use of Antihypertensive Drugs to Outpatients at Internal Medicine Departments of General Hospital

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The purpose of antihypertensive therapy is not only to normalize the blood pressure but also to prevent severe or fatal complications of the cardiovascular system. Since the presence or absence of target organ failure and major dangerous factors influence the prognosis of hypertension, an appropriate evaluation of these risk factors is important. It is therefore necessary to consider such complications when evaluating antihypertensive therapy. In this investigation, we examined the current state regarding the use of antihypertensive drugs and their associated complications in Takarazuka City Hospital, to establish a more effective and safer pharmacotherapy from the pharmacist's viewpoint. A total of 312 patients (138 males, 174 females) who received antihypertensive drugs at the Department of Internal Medicine in our hospital between August 23^<rd> and 27^<th>, 1999 were included in this study. The patients' records were examined with regard to age, the medication received and the complications observed. The most common form of treatment, regardless of age, was calcium channel blockers (Ca blockers), followed by angiotensin converting enzyme inhibitors (ACE-I), and finally α -, and β -adrenergic blockers (α and ,βblockers, respectively). The rates of congestive heart failure (CHF) and ischemic heart disease (IHD) tended to increase with age. On the other hand, those of endocrine metabolic diseases such as diabetes mellitus (DM), hyperlipidemla and gout were either unaffected or tended to decrease with age. The peculiar use ratio of diuretics in patients with CHF was higher than that in non-CHF (p<0. 05). The use of ,9 blockers was slightly higher in IHD. The ratio of a blockers correlated with the rates of DM (p<0. 05) and hyperlipidemia (not significant). In conclusion, due to the variety of the patient profiles and the clinical backgrounds antihypertensive drug therapy has thus become a complex issue. In addition, GL is not applicable in all cases. However, the results of this study suggest that the current state regarding the use of antihypertensive drugs and their associated complications in our hospital was similar to that in previous reports. It is therefore necessary to further accumulate and analyze such findings including the types of treated diseases, the indications and dosage of each applied drug to establish more effective and safer antihypertensive pharmacotherapies.
日本医療薬学会の論文
2001-04-10

Analysis of Current State Regarding the Use of Antihypertensive Drugs to Outpatients at Internal Medicine Departments of General Hospital

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