DISTRIBUTION AND METABOLISM OF SECRETIN AND APROTININ IN ISOLATED PERFUSED RAT PANCREAS
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概要
- 論文の詳細を見る
The distribution and metabolism of secretin and aprotinin were studied in isolated perfused rat pancreas, which were kept under physiological conditions. At ^<125>I- [Tyr^1]secretin perfusion study the radioactivity appeared in the effluent, rapidly attaining an equilibrium with the perfusate. While the intact secretin concentration decreased to 55% of the perfusate ; the distibution space of secretin was estimated to be about 0.11 ml/g pancreas. The ratio of intact secretin to degradated products in the pancreas increased concomitantly with the perfusion of 82 nM secretin. When unlabeled secretin was perfused, immunoreactive secretin concentration in the portal effluent reached also a rapid equilibrium to about 60% of the perfusate. These results suggested that pancreas might clear about 40% of the entering secretin. In the case of ^<125>I-aprotinin perfusion, intact aprotinin fraction was predominant both in the effluent and in the pancreas. The apparent distribution space was about 40% of the volume of pancreas.Meanwhile, when ^<125>I-reduced aprotinin or ^<125>I-[S-carboxamidomethyl]aprotinin was perfused, the decomposed products were significantly increased. These findings indicate that the disulfide bonds in aprotinin molecule play an important role for its stability as well as its antiproteolytic activity.
- 公益社団法人日本薬学会の論文
著者
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IWAKAWA Seigo
Kobe Pharmaceutical University
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Iwakawa S
Department Of Cardiology Miki
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Iwakawa Seigo
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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Okumura K
Department Of Pharmacy Kobe University School Of Medicine
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Okumura Katsuhiko
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Okumura Katsuhiko
Department Of Clinical Evaluation Of Pharmacotherapy Kobe University Graduate School Of Medicine
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Hori Ryohei
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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Okumura K
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Okumura Katsuhiko
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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IWAKAWA SEIGO
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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Okumura Katsuhiko
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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Okumura Katsuhiko
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University:(present Addre
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Hori Ryohei
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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