Effect of Glimepiride and Glibenclamide on S-Warfarin 7-Hydroxylation by Human Liver Microsomes, Recombinant Human CYP2C9.1 and CYP2C9.3(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
The effect of glimepiride on metabolism of S-warfarin to 7-hydroxywarfarin was studied using human liver microsomes and recombinant cytochrome P450 2C9 microsomes (CYP2C9.1 and CYP2C9.3), and was compared with the results from the experiments using glibenclamide as an inhibitor. S-Warfarin 7-hydroxylation by recombinant CYP2C9.1 and CYP2C9.3 was inhibited by glimepiride competitively. The apparent K_i value of glimepiride was lower at CYP2C9.3 than at CYP2C9.1. Glimepiride also inhibited 7-hydroxylation of S-warfarin in a competitive manner by microsomes from human liver which showed the genotypes of CYP2C9, as CYP2C9*1/*1 or CYP2C9*1/*3. The apparent K_i value of glimepiride was lower than that of glibenclamide. These results may provide valuable information for optimizing the anticoagulant activity of warfarin when glimepiride is co-administered to patients.
- 公益社団法人日本薬学会の論文
- 2006-09-01
著者
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IWAKAWA Seigo
Kobe Pharmaceutical University
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KURODA Tsutomu
Department of Fusion Science, The Graduate University for Advenced Studies
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IWAKAWA Seigo
Department of Pharmaceutics, Kobe Pharmaceutical University
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Iwakawa S
Department Of Cardiology Miki
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Iwakawa Seigo
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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Hashimoto Yasuaki
Department of Hospital Pharmacy, Miki City Hospital
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Hashimoto Yasuaki
Department Of Pharmacy Miki City Hospital
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Shinobu Ichikawa
Department Of Cardiology Miki
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Kuroda Tsutomu
Department Of Pharmacy Miki City Hospital
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Kuroda Tsutomu
Department Of Fusion Science The Graduate University For Advenced Studies
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Kuroda T
Okayama Prefectural Univ. Okayama Jpn
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MIYASHITA Kenji
Department of Pharmaceutics, Kobe Pharmaceutical University
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Ichikawa Shinobu
Department Of Cardiology Miki City Hospital
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Miyashita Kenji
Department Of Pharmaceutics Kobe Pharmaceutical University
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Iwakawa Seigo
Department of Cardiology, Miki
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