Effect of Ethanol on the Binding of Warfarin Enantiomers to Human Serum Albumin(Biopharmacy)
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概要
- 論文の詳細を見る
Ethanol is widely used as a pharmaceutical excipient for the solubilization of many hydrophobic drugs for injections. However, there are only few studies about drug interaction with pharmaceutical excipients in the body after injection. In this study, the effect of ethanol (500 HIM) or several alcohols (500 HIM) on the stereoselective binding of warfarin enantiomers to fatty acid-free human serum albumin (HSA) or proteins of commercial albumin preparations was investigated. An ultrafiltration method was used for the separation of unbound warfarin enantiomers. By the addition of ethanol or 1-propanol, the unbound fraction of the 5-enantiomer was decreased. On the other hand, the unbound fraction of the /f-enantiomer was increased by the addition of ethanol or 1-propanol. Unbound fractions of both the S- and /?-enantiomer were decreased by 2-propanol. In various commercial albumin preparations, unbound fractions of both the S- and /t-enantiomer were increased by ethanol. The different effects of ethanol among fatty acid-free HSA and commercial albumin preparations were observed.
- 2007-04-01
著者
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IWAKAWA Seigo
Department of Pharmaceutics, Kobe Pharmaceutical University
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Iwakawa Seigo
伊丹市立伊丹病院 薬剤科
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Iwakawa Seigo
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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TATSUMI Akitoshi
Department of General Thoracic Surgery, Kochi Municipal Hospital
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KADOBAYASHI Muneo
Department of Pharmacy, The Hospital of Hyogo College of Medicine
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Tatsumi Akitoshi
Educational Center For Clinical Pharmacy Kobe Pharmaceutical University:department Of Pharmacy The H
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Tatsumi Akitoshi
Department Of General Thoracic Surgery Kochi Municipal Hospital
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Kadobayashi Muneo
Department Of Pharmacy The Hospital Of Hyogo College Of Medicine
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Iwakawa Seigo
Department of Cardiology, Miki
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