Direct Modulation of Secretin Binding Sites by Gastrin in the Rat Stomach
スポンサーリンク
概要
- 論文の詳細を見る
The effect of gastrin on secretin binding sites in the stomach was studied using the plasma membranes from rat gastric mucosa and vascularly perfused rat stomach. Tetragastrin transiently increased secretin binding to the mucosal plasma membranes. In the perfused stomach secretin binding was also modulated by the inclusion of tetragastrin or human [Leu^<15>] gastrin I in the perfusate. However, histamine did not show such a modulatory effect. Tetragastrin had an insignificant effect on secretin binding sites in rat pancreas. These results suggest that the direct modulation of secretin binding by gastrin to its receptors may be involved in the inhibitory action of secretin on acid secretion induced by gastrin.
- 公益社団法人日本薬学会の論文
著者
-
OKUMURA Katsuhiko
Department of Hospital Pharmacy, Kobe University School of Medicine
-
HORI Ryohei
Department of Pharmacy, Kyoto University Hospital
-
IWAKAWA Seigo
Kobe Pharmaceutical University
-
IWAKAWA Seigo
Department of Pharmaceutics, Kobe Pharmaceutical University
-
Iwakawa S
Department Of Cardiology Miki
-
Iwakawa Seigo
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
-
Okumura K
Department Of Pharmacy Kobe University School Of Medicine
-
Hori R
Kinki Univ. Osaka Jpn
-
Hori Ryohei
Department Of Pharmacy Kyoto University Hospital
-
Hori Ryohei
Department Of Pharmacy Kyoto University Hospital:product Development Laboratory Sankyo Co. Ltd.
-
Okumura Katsuhiko
Department Of Clinical Evaluation Of Pharmacotherapy Kobe University Graduate School Of Medicine
-
Hori Ryohei
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
-
Shinobu Ichikawa
Department Of Cardiology Miki
-
Nomura Hisashi
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
-
Okumura K
Department Of Hospital Pharmacy School Of Medicine Kobe University
-
Hori Ryohei
Kyoto University School Of Medicine Kyoto
-
Okumura Katsuhiko
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
-
Ichikawa Shinobu
Department Of Cardiology Miki City Hospital
-
Okumura Katsuhiko
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
-
Okumura Katsuhiko
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University:(present Addre
-
Hori Ryohei
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
-
Iwakawa Seigo
Department of Cardiology, Miki
関連論文
- Association of Cumulative Cyclosporine Dose with Its Irreversible Nephrotoxicity in Japanese Patients with Pediatric-Onset Autoimmune Diseases(Biopharmacy)
- MEAN RESIDENCE TIME IN ORGANS IN TOXICOKINETIC STUDIES
- PROTECTIVE EFFECT OF N-ACYL AMINO ACID DERIVATIVES ON CEPHALORIDINE NEPHROTOXICITY IN RABBITS
- Reversal Effects of Ca2+ Antagonists on Multidrug Resistance via Down-regulation of MDR1 mRNA
- Three-Dimensional, but not Two-Dimensional, Culture Results in Tumor Growth Enhancement after Exposure to Anticancer Drugs
- Knock-down of Sorcin Induces Up-regulation of MDR1 in HeLa Cells(Molecular and Cell Biology)
- Effects of Reactive Oxygen Species on Cell Proliferation and Death in HeLa Cells and Its MDR1-Overexpressing Derivative Cell Line
- Effects of carvedilol on MDR1-mediated multidrug resistance : comparison with verapamil
- Effects of St John's Wort and Hypericin on Cytotoxicity of Anticancer Drugs
- Cytotoxic Effects of 27 Anticancer Drugs in HeLa and MDR1-Overexpressing Derivative Cell Lines
- Antiproliferative Activity of Rhinacanthus nasutus (L.) KURZ Extracts and the Active Moiety, Rhinacanthin C(Pharmacology)
- TRANSPORT MECHANISMS OF BESTATIN IN INTESTINAL AND RENAL BRUSH-BORDER MEMBRANES
- TRANSPORT MECHANISMS OF β-LACTAM ANTIBIOTICS IN INTESTINAL BRUSH-BORDER MEMBRANES
- TRANSPORT MECHANISMS OF CATIONIC DRUGS IN RAT RENAL BRUSH-BORDER AND BASOLATERAL MEMBRANES
- TRANSPORT OF DRUGS BY PLASMA MEMBRANE VESICLES ISOLATED FROM RAT KIDNEY CORTEX
- Intradermal Concentration of Hydroquinone after Application of Hydroquinone Ointments Is Higher than Its Cytotoxic Concentration(Biopharmacy)
- Different Contribution of CYP2C19 in the in Vitro Metabolism of Three Proton Pump Inhibitors
- MDR1 Haplotype Frequencies in Japanese and Caucasian, and in Japanese Patients with Colorectal Cancer and Esophageal Cancer
- MDR1 C3435T Polymorphism Is Predictive of Later Onset of Ulcerative Colitis in Japanese(Biopharmacy)
- Reversal Effects of Antifungal Drugs on Multidrug Resistance in MDR1-Overexpressing HeLa Cells
- Effect of 2-Methoxyestradiol, Buthionine Sulfoximine and Hydrogen Peroxide on the Viability of Renal Carcinoma Cell Lines(ACHN and ACVB)(Biopharmacy)
- IL-1β Genotype-Related Effect of Prednisolone on IL-1β Production in Human Peripheral Blood Mononuclear Cells under Acute Inflammation(Pharmacology)
- Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma
- Effect of Therapeutic Moderate Hypothermia on Multi-drug Resistance Protein 1-Mediated Transepithelial Transport of Drugs
- Comparison of Synthetic DNA Templates with Authentic cDNA Templates in Terms of Quantification by Real-Time Quantitative Reverse Transcription Polymerase Chain Reaction(Analytical Biochemistry)
- 電流検出方式DNAチップを用いた複数遺伝子型同時判定法のMDR1遺伝子への応用
- Comparative Study of Superoxide Dismutase in Normal and Hereditary Cataract (UPL) Rats
- Effects of Polymorphisms of MDR1, MRP1, and MRP2 Genes on Their mRNA Expression Levels in Duodenal Enterocytes of Healthy Japanese Subjects(Biopharmacy)
- MDR1-Mediated Interaction of Digoxin with Antiarrhythmic or Antianginal Drugs
- Factors Influencing the Prediction of Steady State Concentrations of Digoxin
- Interaction of Docetaxel ("Taxotere") with Human P-Glycoprotein
- Cellular Pharmacokinetic Aspects of Reversal Effect of Itraconazole on P-Glycoprotein-Mediated Resistance of Anticancer Drugs
- Inhibitory Effects of a Cyclosporin Derivative, SDZ PSC 833, on Transport of Doxorubicin and Vinblastine via Human P-Glycoprotein
- TRANSPORT CHARACTERISTICS AND CYTOTOXICITY OF CYCLOSPORIN A IN CULTURED KIDNEY EPITHELIAL CELL LINE (LLC-PK_1)
- Effects of Pharmacists' Consultation on Serum Cholesterol Level Using Drug History Notebook or Drug Instruction Sheets for Outpatients with Hypercholesterolemia
- P-gp誘導 Caco-2 細胞 : P-gp高感度 Assay System の構築
- Decreased Diuretic Response to Furosemide in Rats with Acute Hepatic Failure
- Increased Diuretic Response to Furosemide in Rats with Glycerol-Induced Acute Renal Failure
- URINARY EXCRETION AND DIURETIC RESPONSE TO FUROSEMIDE IN RATS AND HUMANS WITH RENAL INSUFFICIENCY
- FATE OF PORCINE AND HUMAN INSULIN AT THE SUBCUTANEOUS INJECTION SITE. II. IN VITRO DEGRADATION OF INSULINS IN THE SUBCUTANEOUS TISSUE OF THE RAT
- FATE OF PORCINE AND HUMAN INSULIN AT THE SUBCUTANEOUS INJECTION SITE. I. DEGRADATION AND ABSORPTION OF INSULINS IN THE RAT
- FATE OF PORCINE AND HUMAN INSULIN IN SUBCUTANEOUSLY ADMINISTERED SITE
- PJ-884 Functional Effects of Renal Stent Placement to Atherosclerotic Renal Artery Stenosis : Factors of Favorable Outcomes(Hypertension, clinical(10)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-133 Impact of Reactive Oxygen Species on Plaque Formation and Vessel Remodeling : Comparison of Histochemical Characteristics and IVUS Finding(Atherosclerosis, Clinical 2 (IHD) : OJ16)(Oral Presentation (Japanese))
- OJ-044 Genetic Variant of Cytochrome P450 2C9 in Patients Receiving Warfarin(Antithrombofic Ttherapy (H) : OJ6)(Oral Presentation (Japanese))
- Pharmacokinetics of Pirarubicin in Pediatric Patients
- Determining the Optimum Dose for the Intravenous Administration of Nicardipine in the Treatment of Acute Heart Failure : A Multicenter Study
- N-Acetyltransferase2 Genotype Correlated with Isoniazid Acetylation in Japanese Tuberculous Patients
- Effects of Secretable SOD Delivered by Genetically Modified Cells on Xanthine/Xanthine Oxidase and Paraquat-Induced Cytotoxicity in Vitro
- Effects of Cu, Zn-Superoxide Dismutase Delivered by Genetically Modified Skin Fibroblasts on Cold-Induced Skin Edema in Rats
- Protective Effect of Transfection with Secretable Superoxide Dismutase (SOD) (a Signal Sequence-SOD Fusion Protein Coding cDNA) Expression Vector on Superoxide Anion-Induced Cytotoxicity in Vitro)
- Effect of Transfection with a Superoxide Dismutase Expression Plasmid on Xanthine/Xanthine Oxidase-Induced Cytotoxicity in Cultured Rat Lung Cells
- Pharmaceutical Studies for Gene Therapy : Expression of Human Cu, Zn-Superoxide Dismutase Gene Transfected by Lipofection in Rat Skin Fibroblasts
- Effect of Clarithromycin on the Bioavailability of Cyclosporin in Rats
- Effect of Transfection with Superoxide Dismutase Expression Plasmid on Superoxide Anion Induced Cytotoxicity in Cultured Rat Lung Cells
- Pharmacokinetics of Zonisamide ; Saturable Distribution into Human and Rat Erythrocytes and into Rat Brain
- Improvement in Wound Healing by Epidermal Growth Factor (EGF) Ointment. II. Effect of Protease Inhibitor, Nafamostat, on Stabilization and Efficacy of EGF in Burn
- Effects of Various Storage Conditions and Alterations of Antioxidant Contents on Chromatic Aberration of Hydroquinone Ointment(Biopharmacy)
- Effect of Serum Triglyceride Concentration on the Fluctuation of Whole Blood Concentration of Cyclosporin A in Patients
- Analysis of Current State Regarding the Use of Antihypertensive Drugs to Outpatients at Internal Medicine Departments of General Hospital
- The Effects of Verapamil on the Gastrointestinal Metabolism of Aprindine
- N-Acetyltransferase 2 Genotype-Related Sulfapyridine Acetylation and Its Adverse Events
- Optimal Dose of Omeprazole for CYP2C19 Extensive Metabolizers in Anti-Helicobacter pylori Therapy : Pharmacokinetic Considerations
- N-Acetyltransferase 2 Genotype Correlates with Sulfasarazine Pharmacokinetics after Multiple Dosing in Healthy Japanese Subjects
- Sufficient effect of 1-week omeprazole and amoxicillin dual treatment for Helicobacter pylori eradication in cytochrome P450 2C19 poor metabolizers
- Pharmaceutical and Clinical Assessment of Hydroquinone Ointment Prepared by Extemporaneous Nonsterile Compounding
- Chitosan Induces Apoptosis via Caspase-3 Activation in Bladder Tumor Cells
- INFLUENCE OF ACUTE RENAL FAILURE ON PHARMACOKINETICS OF PHENOLSULFONPHTHALEIN IN RATS : A COMPARATIVE STUDY IN VIVO AND IN THE SIMULTANEOUS PERFUSION SYSTEM OF LIVER AND KIDNEY
- INCREASED AVAILABILITY OF PROPRANOLOL IN RATS WITH URANYL NITRATE-INDUCED ACUTE RENAL FAILURE
- Effect of Ethanol on the Binding of Warfarin Enantiomers to Human Serum Albumin(Biopharmacy)
- Molecular and Pharmacokinetic Properties of 222 Commercially Available Oral Drugs in Humans
- OE-039 The Comparison of Bare Metal Stents and Sirolimus-eluting Stents in PCI for Chronic Total Occlusion(Coronary revascularization, PCI-01, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- MECHANISM OF RENAL DISTRIBUTION OF AMINOGLYCOSIDE ANTIBIOTICS
- PHARMACOKINETICS AND PHARMACODYNAMICS OF AJMALINE IN DISEASE STATES
- REGULATORY MECHANISMS OF H^+/ORGANIC CATION ANTIPORT SYSTEM IN RAT RENAL BRUSH-BORDER MEMBRANES
- DISPOSITION OF SECRETIN IN RAT STOMACH AND PANCREAS
- GENTAMICIN BINDING TO BRUSH BORDER AND BASOLATERAL MEMBRANES ISOLATED FROM RAT KIDNEY CORTEX
- TRANSPORT CHARACTERISTICS AND CYTOTOXICITY OF AMINOGLYCOSIDE ANTIBIOTICS IN CULTURED KIDNEY EPITHELIAL CELL LINE (LLC-PK_1)
- MECHANISMS OF PHARMACOKINETIC INTERACTION BETWEEN AJMALINE AND QUINIDINE IN RATS
- A NONLINEAR MULTIPLE REGERSSION PROGRAM, MULTI2 (BAYES), BASED ON BAYESIAN ALGORITHM FOR MICROCOMPUTERS
- DISTRIBUTION AND METABOLISM OF HUMAN, PORCINE AND EEL CALCITONIN IN THE ISOLATED PERFUSED RAT KIDNEY
- Effect of Gender on Theophylline Clearance in the Asthmatic Acute Phase in Japanese Pediatric Patients(Biopharmacy)
- Erratum: Effect of Gender on Theophylline Clearance in the Asthmatic Acute Phase in Japanese Pediatric Patients[Biol. Pharm. Bull. 32(2): 304—307]
- The Novel Anticancer Drug KRN5500 Interacts with, but is Hardly Transported by, Human P-Glycoprotein
- Stereoselective Reductive Metabolism of Metyrapone and Inhibitory Activity of Metyrapone Metabolites, Metyrapol Enantiomers, on Steroid 11β-Hydroxylase in the Rat
- Hydrogen–Deuterium (H–D) Exchange Reaction of Warfarin in D2O Solution
- Alteration of Propranolol Pharmacokinetics and Pharmacodynamics by Quinidine in Man
- CHARACTERIZATION OF HIGH MOLECULAR WEIGHT FORMS OF PEPTIDE DRUGS IN VIVO
- IN VIVO CONVERSION OF PEPTIDE DRUGS INTO HIGH MOLECULAR WEIGHT FORMS
- IN VIVO FORMATION OF HIGH MOLECULAR WEIGHT COMPONENTS FROM PEPTIDE DRUGS
- Effect of Oxyethylene Numbers on the Pharmacokinetics of Menatetrenone Incorporated in Oil-in-Water Lipid Emulsions Prepared with Polyoxyethylene-Polyoxypropylene Block Copolymers and Soybean Oil in Rats(Highlighted paper selected by Editor-in-chief,Bioph
- Effect of Ethanol on S-Warfarin and Diclofenac Metabolism by Recombinant Human CYP2C9.1(Biopharmacy)
- Effects of Pharmacists' Consultation on Serum Uric Acid Level in Outpatients with Hyperuricemia
- Effects of Pharmacists' Consultation on Serum Uric Acid Level in Outpatients with Hyperuricemia
- Effect of Glimepiride and Glibenclamide on S-Warfarin 7-Hydroxylation by Human Liver Microsomes, Recombinant Human CYP2C9.1 and CYP2C9.3(Biopharmacy)
- Direct Modulation of Secretin Binding Sites by Gastrin in the Rat Stomach
- Regulation of Epidermal Growth Factor Receptors in Rat Gastric Mucosa : Effect of Gastric Ulceration
- Regulation of Epidermal Growth Factor Receptors in Rat Gastric Mucosa : Effect of Fasting and Sialoadenectomy
- CHANGES IN EGF RECEPTORS ON PLASMA MEMBRANES FROM RAT GASTRIC MUCOSA AND INTERACTION WITH DRUGS
- DISTRIBUTION AND METABOLISM OF SECRETIN AND APROTININ IN ISOLATED PERFUSED RAT PANCREAS