MECHANISM OF RENAL DISTRIBUTION OF AMINOGLYCOSIDE ANTIBIOTICS
スポンサーリンク
概要
- 論文の詳細を見る
The renal accumulation of dibekacin, one of the aminoglycoside antibiotics, was pharmacokinetically analyzed and the mechanism of the renal accumulation of these antibiotics was investigated. The remaining amounts of dibekacin in the kidneys were adequately expressed by the bi-exponential equation. There was no possibility of a covalent bond between dibekacin and the renal tissue components. The renal accumulation of the aminoglycoside antibiotics was explained in terms of the two successive processes, renal tubular reabsorption and electrostatic interaction between these antibiotics and the tissue components. In other words, these antibiotics were reabsorbed at the renal tubules and transported into renal tubular epithelial cells and bound to the tissue components by electrostatic force. The electrostatic interaction also played an important role in increasing the acute toxicities of aminoglycoside antibiotics.
- 公益社団法人日本薬学会の論文
著者
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HORI Ryohei
Department of Pharmacy, Kyoto University Hospital
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Kamiya A
Yamaguchi Univ. Hospital Yamaguchi Jpn
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OKUMURA KATSUHIKO
Institute of Pharmaceutical Sciences, Hiroshima University, School of Medicine
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HORI Ryohei
Pharmaceutical Research and Technology Institute
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Okumura Katsuhiko
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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Hori Ryohei
Department Of Pharmacy Kyoto University Hospital:product Development Laboratory Sankyo Co. Ltd.
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Okumura Katsuhiko
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University:department Of
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Fujita Masataka
Pharmaceutical Development Laboratories Meiji Seika Kaisha Ltd.
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Hori Ryohei
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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Kamiya Akira
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University:department Of
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UMEMURA KOSHIRO
Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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Komiya Izumi
Pharmacology And Toxicology Laboratories Meiji Seika Kaisha Ltd.
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Komiya Izumi
Central Research Laboratories Meiji Seika Kaisha Ltd.
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Umemura Koshiro
Central Research Laboratories Meiji Seika Kaisha Ltd.
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Hori R
Laboratory Of Cell Structure And Function Wood Research Institute Kyoto University
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Hori Ryohei
Kyoto University School Of Medicine Kyoto
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Okumura Katsuhiko
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University:(present Addre
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