URINE FLOW-DEPENDENCE AND INTERSPECIES VARIATION OF THE RENAL REABSORPTION OF SULFANILAMIDE

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概要

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• A physiologically based model for drug reabsorption in renal tubules was applied to sulfanilamide reabsorption kinetics in rats, rabbits and dogs. The reabsorption percent of sulfanilamide decreased with an increase of urine flow rate in the three animal species examined. Furthermore, the reabsorption percent increased with the decrease of the glomerular filtration rate (GFR), even though the urine flow rate normalized by GFR was the same. The power law formula was obtained between AR (l). Pe and the animal body weight. The power was 0.721,which was less than unity. In contrast, σ was not dependent on animal body weight. The reabsorption percent of sulfanilamide in man was calculated using AR (l) Pe and σ obtained from animal data. The value thus calculated was 50-60%, which was comparable to the reported value (52%) in healthy human subjects. Therefore, the reabsorption percent of sulfanilamide in man was successfully predicted by the extrapolation of animal data.

• 公益社団法人日本薬学会の論文

著者

• KOMIYA IZUMI

  Pharmacology and Toxicology Laboratories, Meiji Seika Kaisha, Ltd.

• Komiya I

  Pharmacology And Toxicology Laboratories Meiji Seika Kaisha Ltd.

• Komiya Izumi

  Pharmacology And Toxicology Laboratories Meiji Seika Kaisha Ltd.

関連論文

• A NOVEL METHOD TO PREDICT THE ELIMINATION HALF-LIVES AND THE RENAL EXCRETION MECHANISMS OF CEPHALOSPORINS
• PHARMACOKINETICS OF DIBEKACIN IN RABBITS AND DOGS
• ACUTE TOXICITY AND PHARMACOKINETICS OF DIBEKACIN IN MICE
• MECHANISM OF RENAL DISTRIBUTION OF AMINOGLYCOSIDE ANTIBIOTICS
• URINE FLOW-DEPENDENCE AND INTERSPECIES VARIATION OF THE RENAL REABSORPTION OF SULFANILAMIDE

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