ACUTE TOXICITY AND PHARMACOKINETICS OF DIBEKACIN IN MICE

概要

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The LD_<50> values of dibekacin to mice were determined following three different methods of administration, namely, intravenous constant infusion, intravenous bolus injection, and intramuscular injection. The serum levels of dibekacin were pharmacokinetically analyzed. The differences in LD_<50> values between the methods of administration were discussed from the viewpoints of pharmacokinetics. 1) The LD_<50> value following the intravenous constant infusion was higher than that following the intravenous bolus injection and approached the level of that following the intramuscular injection, when the infusion rate of the drug was decreased by increasing the infusion period. 2) The biological half-life of dibekacin in mice was 24-45 min. 3) The volume of distribution increased as its dose increased, and a linear correlation was noted between log V_d and log (dose). 4) The difference among the maximum serum concentrations calculated with dibekacin following the administration of LD_<50> was small, which coincided with the results of the experiment that the serum concentrations of dibekacin at the death following the administration of LD_<100> were almost the same regardless of the method of administration.
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