Transport of Salicylamide from Intestinal Lumen to Serosal Compartment
スポンサーリンク
概要
- 論文の詳細を見る
This study was aimed to clarify the fate of the perfused drug and the characteristics of the serosal compartment. A portion of rat small intestine immersed in a solution regarded as the serosal compartment was perfused in situ and the permeability of drugs into the mesenteric venous blood and into the serosal solution were determined. The cumulative amounts of salicylamide (SAM) transported to the mesenteric venous blood and the serosal compartment were 19.7 and 45.8% of amount disappeared from the intestinal lumen, respectively and those of benzoic acid (BA) were 47.4 and 12.7%, respectively. The permeability of SAM into the serosal compartment was 2.8 times of that into the mesenteric venous blood, while the permeability of BA into the serosal compartment was only one fourth of that into the mesenteric venous blood.
- 公益社団法人日本薬学会の論文
著者
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UMEMURA KOSHIRO
Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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Umemura K
Toho Univ. Funabashi Jpn
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Umemura Koshiro
Central Research Laboratories Meiji Seika Kaisha Ltd.
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Nishigaki R
Central Research Laboratories Ss Pharmaceutical Co. Ltd.:school Of Pharmaceutical Science Toho Unive
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Oikawa Takayuki
Central Research Laboratories Ss Pharmaceutical Co. Ltd.:school Of Pharmaceutical Science Toho Unive
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Shibasaki Shigeki
Central Research Laboratories Ss Pharmaceutical Co. Ltd.:school Of Pharmaceutical Science Toho Unive
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NISHIGAKI Ryuichiro
Central Research Laboratories, SS Pharmaceutical Co. Ltd.
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