Comparative Study of Superoxide Dismutase in Normal and Hereditary Cataract (UPL) Rats
スポンサーリンク
概要
- 論文の詳細を見る
In the present study, the levels of SOD activity and Cu, Zn-SOD mRNA in the brain, kidney, liver and eye of normal and Upjohn Pharmaceutics Limited (UPL) rats, a new hereditary cataract model derived from Sprague-Dawley rats, were measured. Although the levels of SOD activity in the eye and brain of UPL rats were significantly decreased compared with those of normal rats 3 and 5 weeks after birth, the levels of SOD activities in the kidney and liver were the same in both groups. The levels of Cu, Zn-SOD mRNA in kidney and liver of UPL rats were the same as those of normal controls. The level of Cu, Zn-SOD mRNA in the brain of normal rats 5 weeks after birth was about twofold greater than that of UPL, and that it the eye of UPL rats 3 weeks after birth was significantly decreased compared with that of normal controls. The sequences of cDNA encoding Cu, Zn-SOD and the sequences of the regulatory region of the Cu, Zn-SOD gene were confirmed to be same in normal and UPL rats.These results indicated that the decreases in levels of SOD activity and Cu, Zn-SOD mRNA in the brain and eye of UPL rat were not due to mutation of the genomic Cu, Zn-SOD gene in UPL rats of differences in the sequence of the regulatory region of the Cu, Zn-SOD gene between normal and UPL rats.
- 社団法人日本薬学会の論文
- 2000-12-01
著者
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Ito Yoshimasa
School of Pharmacy, Kinki University
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OKUMURA Katsuhiko
Department of Hospital Pharmacy, Kobe University School of Medicine
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Ito Yoshimasa
School Of Pharmacy
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KOMADA Fusao
Department of Drug Informatics, Faculty of Pharmaceutical Sciences, Josai University
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SAITOH Yukiya
Department of Drug Informatics, Faculty of Pharmaceutical Sciences, Josai University
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KAWABATA Haruno
Department of Drug Informatics, Faculty of Pharmaceutical Sciences, Josai University
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OHSAKA Noriko
Department of Drug Informatics, Faculty of Pharmaceutical Sciences, Josai University
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TOMOHIRO Masayuki
Research and Development, Research Department, Pharmacia & Upjohn
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TERAO Motome
Pharmaceutical Research and Technology Institute
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HORI Ryohei
Pharmaceutical Research and Technology Institute
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Ohsaka Noriko
Department Of Drug Informatics Faculty Of Pharmaceutical Sciences Josai University
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Tomohiro Masayuki
Research And Development Research Department Pharmacia & Upjohn:(present Address)department Of M
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Terao M
Pharmaceutical Research And Technology Institute
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Komada Fusao
Japan And Department Of Drug Informatics Faculty Of Pharmaceutical Sciences Jyosai University
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Komada Fusao
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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Kawabata Haruno
Japan And Department Of Drug Informatics Faculty Of Pharmaceutical Sciences Jyosai University
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Okumura Katsuhiko
Department Of Clinical Evaluation Of Pharmacotherapy Kobe University Graduate School Of Medicine
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Ito Yoshimasa
School Of Pharmaceutical Sciences Kinki University
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Komada F
Department Of Pharmacy Kobe University School Of Medicine
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Saitoh Yukiya
Japan And Department Of Drug Informatics Faculty Of Pharmaceutical Sciences Jyosai University
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Okumura K
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Ito Yoshimasa
School of Pharmaceutical science, Kinki University
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