Delay of Cataract Development in the Shumiya Cataract Rat by the Administration of Drinking Water Containing High Concentration of Magnesium Ion(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
We discovered that the cataract development in the Shumiya cataract rat (SCR) can be prevented by the administration of deep-sea drinking water (DDW). A standard diet based on the American Institute of Nutrition guidelines (AIN-76) and DDW containing a high mineral concentration such as low, medium and high Mg^<2+> content (50, 200 and 1000mg of Mg^<2+>/l, respectively) were used in this study. SCRs were freely fed with combinations of the standard diet and purified water or DDW during 5-15 weeks of age. The opacities of SCR lenses were documented by anterior eye segment analysis system EAS-1000. The onset of opacification of cataractous SCR lenses administered a combination of standard diet and purified water started at 11 weeks of age, and mature cataracts had formed at 13 weeks of age. However, the supplementation of Mg^<2+> by administration with medium DDW showed the greatest effect of delay of cataract onset in SCR. In addition, even cataractous SCR lenses at 14 weeks of age showed differences in opacity level. The opacification and Ca^<2+> of the lenses in cataractous SCR administered medium DDW were lower than those administered purified water. In conclusion, the present study demonstrates that administration of DDW potently delays cataract development in SCR, and this may be caused by inhibiting the increase in Ca^<2+> levels in the lens.
- 社団法人日本薬学会の論文
- 2006-06-01
著者
-
Nagai Noriaki
School of Pharmacy, Kinki University
-
Ito Yoshimasa
School of Pharmacy, Kinki University
-
Ito Yoshimasa
School Of Pharmacy Kinki Univ.
-
Nagai Noriaki
School Of Pharmacy Kinki Univ.
-
Nagai Noriaki
School Of Pharmaceutical Sciences Kindai University
-
TAI Hideyuki
Technical Development Department, AKO KASEI Co., Ltd.
-
HATAGUCHI Yoshihiro
Technical Development Department, AKO KASEI Co., Ltd.
-
NAKAGAWA Koji
Technical Development Department, AKO KASEI Co., Ltd.
-
Ito Yoshimasa
School Of Pharmacy Kindai University:pharmaceutical Research And Technology Institute Kindai Univers
-
INOMATA Mitsushi
Department of Protein Biochemistry, Tokyo Metropolitan Institute of Gerontology
-
SHUMIYA Seigo
Department of Laboratory Animal Science, Tokyo Metropolitan Institute of Gerontology
-
Inomata M
Cellular Signaling Group Research Team For Functional Genomics Tokyo Metropolitan Institute Of Geron
-
Inomata Mitsushi
Department Of Enzyme Biochemistry Tokyo Metropolitan Institute Of Gerontology
-
Ito Yoshimasa
School Of Pharmaceutical Sciences Kinki University:pharmaceutical Research And Tchnology Institute K
-
Hataguchi Yoshihiro
Technical Development Department Ako Kasei Co. Ltd.
-
Ito Yoshimasa
School Of Pharmaceutical Sciences Kinki University
-
Tai Hideyuki
Technical Development Department Ako Kasei Co. Ltd.
-
Shumiya S
Department Of Laboratory Animal Science Tokyo Metropolitan Institute Of Gerontology
-
Shumiya Seigo
Department Of Laboratory Animal Science Tokyo Metropolitan Institute Of Gerontology
-
Nakagawa Koji
Technical Dev. Div. Ako Kasei Co. Ltd.
-
Nagai Noriaki
School of Pharmaceutical Sciences, Kindai University
-
Nagai Noriaki
School of Pharmaceutical science, Kinki University
-
Ito Yoshimasa
School of Pharmaceutical science, Kinki University
関連論文
- Comparison of Corneal Wound Healing Rates after Instillation of Commercially Available Latanoprost and Travoprost in Rat Debrided Corneal Epithelium
- Enhancing Effects of Sericin on Corneal Wound Healing in Otsuka Long-Evans Tokushima Fatty Rats as a Model of Human Type 2 Diabetes
- Enhancing Effects of Sericin on Corneal Wound Healing in Rat Debrided Corneal Epithelium
- Preparation of Ophthalmic Formulations Containing Cilostazol as an Anti-glaucoma Agent and Improvement in Its Permeability through the Rabbit Cornea
- Contribution of Aldehyde Dehydrogenase 3A1 to Disulfiram Penetration through Monolayers Consisting of Cultured Human Corneal Epithelial Cells(Biopharmacy)
- Kinetic Analysis of the Rate of Corneal Wound Healing in Otsuka Long-Evans Tokushima Fatty Rats, a Model of Type 2 Diabetes Mellitus
- Disulfiram Reduces Elevated Blood Glucose Levels in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats, a Model of Type 2 Diabetes
- Preventive Effect of Co-administration of Water Containing Magnesium Ion on Indomethacin Induced Lesions of Gastric Mucosa in Adjuvant-Induced Arthritis Rat(Biopharmacy)
- Preventive Effect of Water Containing Magnesium Ion on Paw Edema in Adjuvant-Induced Arthritis Rat(Biopharmacy)
- Effect of Magnesium Deficiency on Intracellular ATP Levels in Human Lens Epithelial Cells(Biochemistry)
- Inhibitors of Inducible Nitric Oxide Synthase Prevent Damage to Human Lens Epithelial Cells Induced by Interferon-Gamma and Lipopolysaccharide(Biopharmacy)
- Deep-Sea Water Improves Cardiovascular Hemodynamics in Kurosawa and Kusanagi-Hypercholesterolemic (KHC) Rabbits(Pharmacology)
- Comparison of the Mechanisms of Cataract Development Involving Differences in Ca^ Regulation in Lenses among Three Hereditary Cataract Model Rats(Biochemistry)
- Effect of Disulfiram Eye Drops on Lipid Peroxide Formation via Excessive Nitric Oxide in Lenses of Hereditary Cataract ICR/f Rats(Biopharmacy)
- Effects of Magnesium Content in the Feed on Cataract Development in Shumiya Cataract Rat
- Delay of Cataract Development in the Shumiya Cataract Rat by the Administration of Drinking Water Containing High Concentration of Magnesium Ion(Biopharmacy)
- Delay in ICR/f Rat Lens Opacification by the Instillation of Eye Drops Containing Disulfiram and Hydroxypropyl-β-cyclodextrin Inclusion Complex(Biopharmacy)
- Preventive Effect of Eye Drops of Liposomes Containing Disulfiram and Cefmetazole on Selenite-Induced Cataract in Rat Pups
- Comparative Study of Superoxide Dismutase in Normal and Hereditary Cataract (UPL) Rats
- Effects of Lipid Composition on the Transcorneal Penetration of Liposomes Containing Disulfiram, a Potential Anti-cataract Agent, in the Rabbit
- Aminoguanidine-Treatment Results in the Inhibition of Lens Opacification and Calpain-Mediated Proteolysis in Shumiya Cataract Rats (SCR)^1
- Involvement of DNase II-Like Acid DNase in the Cataract Formation of the UPL Rat and the Shumiya Cataract Rat(Biochemistry)
- Involvement of Interleukin 18 in Cataract Development in Hereditary Cataract UPL Rats
- Degradation of Fodrin by m-Calpain in Fibroblasts Adhering to Fibrillar Collagen I Gel
- CELL SPIKE FORMATION AND m-CALPAIN ACTIVATION IN SKIN FIBROBLASTS ADHERING TO FIBRILLAR COLLAGEN I.
- Immunohistochemical Study of Calpain-Mediated α-Crystallin Proteolysis in the UPL Rat Hereditary Cataract
- Effect of Low Protein and Low Energy Diet on Physiological Status and Digestibility of F344 Rats
- Development of a Diet for Long-Term Raising of F344 Rats : Relationship between Dietary Digestible Crude Protein Content and Digestible Energy Conetnt
- Establishment and Characteristics of Four Sub-Strains of F344 Rats Reared on Various Low Protein and Low Energy Diets
- Involvement of Calpain in Osteoclastic Bone Resorption
- Correlation between Hyper-Sensitivity to Hydrogen Peroxide and Low Defense against Ca2+ Influx in Cataractogenic Lens of Ihara Cataract Rats
- Lens Reconstruction After Mature Cataract in SCR Rat
- Preventive Effect of Co-administration of Water Containing Magnesium Ion on Indomethacin Induced Lesions of Gastric Mucosa in Adjuvant-Induced Arthritis Rat
- Co-administration of Water Containing Magnesium Ion Prevents Loxoprofen-Induced Lesions in Gastric Mucosa of Adjuvant-Induced Arthritis Rat
- Therapeutic Effects of Gel Ointments Containing Tranilast Nanoparticles on Paw Edema in Adjuvant-Induced Arthritis Rats
- Degradation of Fodrin by m-Calpain in Fibroblasts Adhering to Fibrillar Collagen I Gel