Deep-Sea Water Improves Cardiovascular Hemodynamics in Kurosawa and Kusanagi-Hypercholesterolemic (KHC) Rabbits(Pharmacology)
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概要
- 論文の詳細を見る
Deep-sea water is rich in minerals, e.g., Mg, Ca, and K which have been considered to be associated with prevention of cardiovascular disease. We investigated the effect of deep-sea water on cardiovascular hemodynamics in Kurosawa and Kusanagi-Hypercholesterolemic (KHC) rabbits. Deep-sea water was pumped in the offing of Cape Muroto in Japan and the mineral constituents were refined to a degree of hardness of 1000. Twenty four 4-month-old KHC rabbits were given refined deep-sea water (n=12) and tap water (n=12) for 6 months. Pressure and flow waves at the ascending aorta were recorded under pentobarbital anesthesia. Systolic, diastolic, pulse and mean arterial pressures and total peripheral resistance were significantly lower in the deep-sea water group than in the control group. There were no significant differences in changes in serum lipid levels, plasma renin and angiotensin converting enzyme activities and electrolyte levels except for Mg^<2+> after the feeding of the water between the two groups. A slight increase in serum Mg^<2+> level in the deep-sea water group may not account for the inhibition of mild hypertension. From our results, we conclude that deep-sea water could improve cardiovascular hemodynamics, even though the factors which affect the blood pressure are still unknown.
- 社団法人日本薬学会の論文
- 2008-01-01
著者
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Kimura Shuichi
Department Of Cellular And Integrative Physiology Fukushima Medical University School Of Medicine
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Shimizu Tsuyoshi
Shimizu Institute Of Space Physiology Suwa Maternity Clinic
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Shimizu Tsuyoshi
福島県立医科大学 医学部生理学
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KATSUDA Shin-ichiro
Department of Physiology, Fukushima Medical University School of Medicine
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Kimura Shuichi
Department Of Applied Biological Chemistry Faculty Of Agriculture Tohoku University
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NAKAGAWA Koji
Technical Development Department, AKO KASEI Co., Ltd.
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YASUKAWA Takeshi
Technical Development Division, Ako Kasei, Co., Ltd.
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MIYAKE Masao
Department of Cellular and Integrative Physiology, Fukushima Medical University School of Medicine
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YAMASAKI Masao
Department of Cellular and Integrative Physiology, Fukushima Medical University School of Medicine
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KATAHIRA Kiyoaki
Experimental Animal Research Center Fukushima Medical University School of Medicine
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MOHRI Motohiko
Nippon Marine Enterprises, Ltd.
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HAZAMA Akihiro
Department of Cellular and Integrative Physiology, Fukushima Medical University School of Medicine
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Katsuda S
Department Of Cellular And Integrative Physiology School Of Medicine Fukushima Medical University
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Kimura S
Laboratory Of Nutrition Graduate School Of Agricultural Science Tohoku University
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Miyake Masao
Department Of Cellular And Integrative Physiology School Of Medicine Fukushima Medical University
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Miyake Masao
Department Of Cell Science Institute Of Biomedical Sciences School Of Medicine Fukushima Medical Uni
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Hazama Akihiro
Department Of Cellular And Integrative Physiology School Of Medicine Fukushima Medical University
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Mohri Motohiko
Nippon Marine Enterprises Ltd.
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Yamasaki Masao
Department Of Cellular And Integrative Physiology Fukushima Medical University School Of Medicine
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Katsuda Shin-ichiro
Department Of Cellular And Integrative Physiology School Of Medicine Fukushima Medical University
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Yamasaki Masao
Department Of Biochemistry And Applied Biosciences Faculty Of Agriculture University Of Miyazaki
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Shimizu T
Shimizu Institute Of Space Physiology Suwa Maternity Clinic
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Yasukawa Takeshi
Technical Development Division Ako Kasei Co. Ltd.
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Katahira Kiyoaki
Experimental Animal Center Fukushima Medical University School Of Medicine
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Nakagawa Koji
Technical Dev. Div. Ako Kasei Co. Ltd.
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Yamasaki Masao
Department Of Biochemistry And Applied Biosciences Faculty Of Agriculture Miyazaki University
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Nakagawa Koji
Technical Development Division Ako Kasei Co. Ltd.
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Shimizu Tsuyoshi
Shimizu Institute Of Space Physiology
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Kamiyama Shin
Gene Research Center Tohoku University
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Hazama Akihiro
Department Of Cellular And Integrative Physiology Fukushima Medical University School Of Medicine
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