Lecithin : Cholesterol Acyltransferase Reduces the Adverse Effects of Oxidized Low-Density Lipoprotein while Incurring Damage Itself(Biochemistry & Molecular Biology)
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概要
- 論文の詳細を見る
In this study, we tried to determine (a) whether there is any permanent effect of oxLDL on the LCAT molecule and its activator lipoprotein apoA-I, and (b) the fate of oxLDL after its exposure to LCAT and apoA-I. Purified LCAT and LDL/oxLDL was incubated at 37℃ for 1h, and separated by gel-permeation chromatography. Its activity was significantly less (30% less) after separating from oxLDL compared to that of LDL. Cofactor activity of isolated apoA-I (incubated with LDL/oxLDL) was found affected by oxLDL. These results indicate modification of the LCAT and apoA-I molecule. But LCAT was found more affected compared to apoA-I in terms of LCAT activity. We are also reporting a novel function of LCAT. It was found to reduce the adverse effects of oxLDL, for example, ability to affect the LCAT activity and TBARS value. This ability of LCAT to repair oxLDL was dose-dependent. But there was no change in its REM values or fluorescence intensity.
- 社団法人日本農芸化学会の論文
- 2001-11-23
著者
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KOMAI Michio
Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
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Kimura Shuichi
Department Of Cellular And Integrative Physiology Fukushima Medical University School Of Medicine
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FURUKAWA Yuji
Laboratory of Nutrition, Department of Science of Food Function and Health, Graduate School of Agric
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Ito Mitsuru
Agroscience Research Laboratories Sankyo Agro Co. Ltd.
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Komai Michio
Tohoku Univ Lab Nutrition
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Komai Michio
Laboratories Of Nutrition Graduate School Of Life Science And Agriculture Tohoku University
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Furukawa Yuji
Laboratory Of Nutrition Department Of Applied Biological Chemistry Faculty Of Agriculture Tohoku Uni
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Kimura Shuichi
Department Of Applied Biological Chemistry Faculty Of Agriculture Tohoku University
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Ito M
Laboratory Of Nutrition Graduate School Of Agricultural Science Tohoku University
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Ito M
Agroscience Research Laboratories Sankyo Agro Co. Ltd.
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Furukawa Yuji
Lab. Of Nutrition Graduate School Of Agricultural Sci. Tohoku Univ.
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Kimura S
Laboratory Of Nutrition Graduate School Of Agricultural Science Tohoku University
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Howlader Zakir
Laboratory Of Nutrition Graduate School Of Agricultural Science
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Murakami Y
Laboratory Of Nutrition Graduate School Of Agricultural Science
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Makino Yoshio
Makino Dermatology Clinic
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ITO Michiko
Laboratory of Nutrition, Faculty of Agriculture, Tohoku University
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Ito Michiko
Laboratory Of Nutrition Graduate School Of Agricultural Science Tohoku University
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Katsuda Shin-ichiro
Department Of Cellular And Integrative Physiology School Of Medicine Fukushima Medical University
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KAMIYAMA Shin
Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
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MURAKAMI Yohei
Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
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Komai Michio
Laboratory Of Nutrition Graduate School Of Agricultural Science Tohoku University
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Kamiyama Shin
Laboratory Of Cell Biology Department Of Bioinformatics Faculty Of Engineering Soka University
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Kamiyama Shin
Gene Research Center Tohoku University
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