The Effect of Various Phospholipids on Plasma Lipoproteins and Liver Lipids in Hypercholesterolemic Rats.

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概要

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• Rats were fed a hypercholesterolemic diet (5% lard, 0.5% cholesterol, and 0.25% sodium cholate) containing 5% of dietary phospholipid as safflower phospholipid (SAP), soybean phospholipid (SOP), or egg yolk phospholipid (EGP), or 5% of soybean oil (SO) as a control for 4 weeks. The concentrations of plasma cholesterol were significantly higher in rats fed the EGP diet than those of the other diets. Similarly, the concentrations of chylomicron plus very low density lipoprotein (VLDL) cholesterol were higher in rats fed the EGP diet. The phospholipid diets induced a significant increase of high density lipoprotein (HDL) cholesterol in comparision with the SO diet. The concentrations of liver cholesterol were significantly lower in rats fed the phospholipid diets than those of the SO diet. Among phospholipid-fed rats, the SAP and SOP diets decreased the concentrations of liver cholesterol compared with the EGP diet. The activity of plasma lecithin-cholesterol acyl-transferase (LCAT) was significantly increased in rats fed the phos-pholipid diets. The phospholipid diets caused an enhanced excretion of neutral steroids into feces. Among phospholipid-fed rats, the SAP and SOP diets increased the excretion of fecal neutral steroids compared with the EGP diet. The fatty acid composition of HDL phospholipid was slightly reflected by the major dietary fat source. These results suggest that SAP and SOP inhibit markedly the absorption of dietary cholesterol in the small intestine of hypercholesterolemic rats and that the effect of SAP and SOP on plasma cholesterol metabolism may be different from that of EGP.

• 財団法人 学会誌刊行センターの論文

著者

• Furukawa Yuji

  Laboratory Of Nutrition Department Of Applied Biological Chemistry Faculty Of Agriculture Tohoku Uni

• Iwata Toshio

  Department Of Orthodontics School Of Dentistry Aichi-gakuin University

• Kimura Shuichi

  Laboratory Of Nutrition Faculty Of Agriculture Tohoku University

• KIMURA Yoshiharu

  Laboratory of Nutrition, Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University

• TSUTSUMI Kentarou

  Department of Research and Development, The Rinoru Oil Mills Co., Ltd

• KIMURA Shuichi

  Laboratory of Nutrition Chemistry, Department of Food Chemistry, Faculty of Agriculture, Tohoku University

• IWATA Toshio

  Department of Research and Development, The Rinoru Oil Mills Co., Ltd

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