STUDIES ON PANTOTHENIC ACID ANTAGONISTS

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概要

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• 1. Analogues of pantothenic acid, i.e., ω-methyl pantothenic acid, pantoyltaurine, ω-methyl pantoyltaurine and analogues of pantethine i.e., ω-methyl pantethine, bis (N-pantoyl-β-aminoethyl) disulfide, bis (N-methyl pantoyl-β-aminoethyl) disulfide, were synthesized and the inhibitory effects of these analogues on lactic acid bacteria were examined and inhibition indexes were calculated.2. Inhibitory effects of these analogues on germination of higher plants, i.e., "yukina" and barley, were also studied. It was observed that the analogues inhibited the germination and growth of the higher plants, and the inhibitory actions were considerably reversed by the presence of an additional equimolecular amount of pantothenic acid (PaA). Furthermore, the existence of antagoism between pantoic acid, a PaA precursor, and its analogue in the germination of higher plants was shown.3. The possibility to induce a nutritional deficiency in the chick embryo by injecting PaA analogue, ω-methyl PaA, was found. A lethal dose of ω-methyl PaA on the second day of incubation was 10.0mg per egg and this inhibitory effects were remarkably prevented by a simultaneous injection of PaA. Interference ratio (analogue: vitamin) was roughly 200:1.4. In the animal experiment, the weight gain of the male DD-strain mice diminished proportionately with the level of supplemented ω-methyl PaA. The inhibitory effects were prevented by a simultaneous addition of PaA. "Interference ratio" was found to be 100:1 to 60:1. Deficiency syndromes induced by ω-methyl PaA were observed.5. Effects of PaA analogue and pantetheine analogues on the acetylation of sulfanilamide in pigeon liver homogenate were studied. A PaA analogue, ω-methyl PaA, was inert for acetylation, but a pantetheine analogue, ω-methyl pantethine, showed a remarkable inhibition.6. Effects of these analogues were discussed and the mechanism of their interference action were also discussed.

• 日本ビタミン学会の論文

著者

• KIMURA Shuichi

  Laboratory of Nutrition Chemistry, Department of Food Chemistry, Faculty of Agriculture, Tohoku University

• ARIYAMA HISASHI

  Laboratory of Nutrition, Faculty of Agriculture, Tohoku University

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• STUDIES ON PANTOTHENIC ACID ANTAGONISTS

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