Vitamin K Suppresses Lipopolysaccharide-Induced Inflammation in the Rat
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概要
- 論文の詳細を見る
Vitamin K (K) is essential for blood coagulation and bone metabolism in mammals. K acts as a cofactor in the posttranslational synthesis of γ-carboxyglutamic acid from glutamic acid residues. In addition to the liver and bone, K is found in the brain, heart, kidney and gonadal tissue. However, the physiological role of K in these various organs is not yet fully understood. It is likely that K has functions other than its role as a cofactor of protein γ-glutamyl carboxylation. We used in this study the DNA microarray technique to identify the effect of K status on gene expression in the rat liver. The expression of genes involved in the acute inflammation response was enhanced in rats fed with a K-deficient diet relative to the control and K1-supplemented diet groups. Moreover, dietary supplementation with K1 suppressed the inflammation induced by lipopolysaccharide administration. These results indicate that orally administrated K1 suppressed inflammation in the rat.
- 社団法人 日本農芸化学会の論文
- 2006-04-23
著者
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Hiwatashi Kazuyuki
Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
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SHIRAKAWA Hitoshi
Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
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KOMAI Michio
Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
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Ohsaki Yusuke
Tohoku Univ, Lab Nutrition
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Hiwatashi Kazuyuki
秋田県農林水産技術センター総合食品研究所
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Hiwatashi Kazuyuki
Akita Res. Inst. Of Food And Brewing
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Hiwatashi Kazuyuki
東北大学 農学研究科栄養学
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OHSAKI Yusuke
Laboratory of Nutrition, Department of Science of Food Function and Health, Graduate School of Agric
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FURUKAWA Yuji
Laboratory of Nutrition, Department of Science of Food Function and Health, Graduate School of Agric
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MIZUTANI Takeo
ALA Research Center
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白川 仁
東理大・基礎工・生物工
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Komai Michio
Tohoku Univ Lab Nutrition
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Komai Michio
Laboratories Of Nutrition Graduate School Of Life Science And Agriculture Tohoku University
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Ohsaki Yusuke
Tohoku Univ Lab Nutrition
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Furukawa Yuji
Laboratory Of Nutrition Department Of Applied Biological Chemistry Faculty Of Agriculture Tohoku Uni
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Furukawa Yuji
Lab. Of Nutrition Graduate School Of Agricultural Sci. Tohoku Univ.
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Shirakawa Hitoshi
Tohoku Univ Lab Nutrition
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Hori K
Kao Co. Ltd. Tochigi Jpn
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Hori Kazuyuki
The Central Research Laboratory Hitachi Ltd.
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Shirakawa Hitoshi
Laboratory Of Nutrition
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Komai Michio
Laboratory Of Nutrition Graduate School Of Agricultural Science Tohoku University
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