Yamabushitake Mushroom (Hericium erinaceus) Improved Lipid Metabolism in Mice Fed a High-Fat Diet

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概要

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• The effects of dietary Yamabushitake mushroom (Hericium erinaceus) on lipid metabolism were examined. C57BL/6J mice were fed a high-fat diet containing hot-water extract (HW-E) and an ethanol extract (EtOH-E) of Yamabushitake mushroom. Administration of HW-E or EtOH-E with a high-fat diet for 28 d resulted in a significant decrease in body weight gain, fat weight, and serum and hepatic triacylglycerol levels. Our in vitro experiments indicated that EtOH-E acts as an agonist of peroxisome proliferator-activated receptor α (PPARα). Quantitative analyses of hepatic mRNA levels revealed that EtOH-E administration resulted in up-regulation of mRNA for a number of PPARα-regulating genes in spite of the fact that the gene expression of PPARα did not change. These results suggest that EtOH-E improves lipid metabolism in mice fed a high-fat diet, and that these effects were mediated by modulation of lipid metabolic gene expression, at least in part via activation of PPARα.

• 社団法人 日本農芸化学会の論文
• 2010-07-23

著者

• Hiwatashi Kazuyuki

  Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University

• Kosaka Yasuyuki

  Sakamoto Bio Co., Ltd.

• Suzuki Nao

  Akita Research Institute for Food and Brewing (ARIF)

• HATA Keishi

  Akita Research Institute for Food and Brewing (ARIF)

• MUKAIYAMA Toshiyuki

  Sakamoto Bio Co., Ltd.

• SAKAMOTO Kenji

  Sakamoto Bio Co., Ltd.

• SHIRAKAWA Hitoshi

  Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University

• KOMAI Michio

  Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University

• Hata Keishi

  Akita Res. Inst. For Food And Brewing (arif)

• Hiwatashi Kazuyuki

  秋田県農林水産技術センター総合食品研究所

• Hiwatashi Kazuyuki

  東北大学 農学研究科栄養学

• 白川 仁

  東理大・基礎工・生物工

• Hirano Kaoru

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Komai Michio

  Tohoku Univ Lab Nutrition

• Komai Michio

  Laboratories Of Nutrition Graduate School Of Life Science And Agriculture Tohoku University

• Suzuki Nao

  Akita Res. Inst. Of Food And Brewing

• 駒井 三千夫

  東北大(農)農芸化学

• Kojima Hiroaki

  R & D Company Kobayashi Pharmaceutical Co. Ltd.

• Shirakawa Hitoshi

  Tohoku Univ Lab Nutrition

• Hori K

  Kao Co. Ltd. Tochigi Jpn

• Hori K

  Akita Res. Inst. Of Food And Brewing

• Hori Kazuyuki

  The Central Research Laboratory Hitachi Ltd.

• 駒井 三千夫

  東北大学大学院農学研究科

• Hata Keishi

  Akita Res. Inst. Of Food And Brewing

• Kojima Hiroaki

  R&d Co. Kobayashi Pharmaceutical Co. Ltd.

• Suzuki Nao

  Akita Research Institute Of Food And Brewing

• Hata K

  Akita Research Institute Of Food And Brewing

• Mukaiyama Toshiyuki

  Sakamoto Bio Co. Ltd.

• Sakamoto Kenji

  Sakamoto Bio Co. Ltd.

• Kojima Hiroaki

  Kobayashi Pharmaceutical Co. Ltd. R&d Company

• Shirakawa Hitoshi

  Laboratory Of Nutrition

• Kosaka Yasuyuki

  Sakamoto Bio Co. Ltd.

• Komai Michio

  Laboratory Of Nutrition Graduate School Of Agricultural Science Tohoku University

• 白川 仁

  東北大・院農

• KOMAI Michio

  Laboratory of Nutrition, Faculty of Agriculture, Tohoku University

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