Induction of Apoptosis with an Extract of Actinidia polygama Fruit in the Promyelocytic Leukemia Cell Line HL-60

スポンサーリンク

概要

• 論文の詳細を見る

• Common small fruit produced naturally in Japan is attracted as healthy food. We studied on inhibitory activity of several small fruit extracts on growth of cancer cells to look for a candidate of healthy food or low toxic anticancer drugs. Among the fruit extracts examined, Actinidia polygama (Matatabi) extract had dose-dependent potent inhibitory activity against the growth of a promyelocytic leukemia cell line, HL-60, but was less effective on a colon cancer cell line, LS-174T, or normal human dermal fibroblast cells. We examined a part of the responsible mechanism of growth inhibition of HL-60 cells. Active agents in A. polygama fruit were heat-stable and small molecular weight of less than 1000. HL-60 cells incubated with an extract of A. polygama fruit induced apoptosis, which was detected by electrophoretic DNA fragmentation, morphological chromatin condensation and the TUNEL method with flow cytometry.

• 公益社団法人日本薬学会の論文
• 2002-08-01

著者

• Hata Keishi

  Akita Res. Inst. For Food And Brewing (arif)

• Yoshizawa Yuko

  Fac. Of Bioresource Sciences Akita Prefectural Univ.

• Murofushi Noboru

  Bio-organic Chemistry Akita Prefectural University

• YOSHIZAWA Yuko

  Faculty of Bioresource Sciences, Akita Prefectural University

• Yoshizawa Yuko

  Bio-organic Chemistry Akita Prefectural University

• Iwashita Jun

  Molecular Biology Lab. Fac. Of Bioresource Sciences Akita Prefectural Univ.

• Abe Tatsuya

  Molecular Biology Lab. Fac. Of Bioresource Sciences Akita Prefectural Univ.

• Fukiya Yoshihiro

  Molecular Biology, Akita Prefectural University

• Izumi Yoshikatsu

  Molecular Biology, Akita Prefectural University

• Izumi Yoshikatsu

  Molecular Biology Akita Prefectural University

• Fukiya Yoshihiro

  Molecular Biology Akita Prefectural University

関連論文

• Paenidase, a Novel D-Aspartyl Endopeptidase from Paenibacillus sp. B38 : Purification and Substrate Specificity
• Stimulative Effects of (22E,24R)-Ergosta-7,22-diene-3β,5α,6β-triol from Fruiting Bodies of Tricholoma auratum, on a Mouse Osteoblastic Cell Line, MC3T3-E1
• The Occurrence of Renin Inhibitor in Rice: Isolation, Identification, and Structure-Function Relationship
• Phylogenetic status of a lung fluke in the Philippines based on mitochondrial genome
• Differentiation of B16-BL6 Melanoma Cells into Microtubule-Associated Protein 2-Positive Cells after Treatment with the Histone Deacetylase Inhibitors Butyrate and Trichostatin A
• Reduction of Blood Pressure by Soybean Saponins, Renin Inhibitors from Soybean, in Spontaneously Hypertensive Rats
• Yamabushitake Mushroom (Hericium erinaceus) Improved Lipid Metabolism in Mice Fed a High-Fat Diet
• Suppression of Murine Preadipocyte Differentiation and Reduction of Visceral Fat Accumulation by a Petasites japonicus Ethanol Extract in Mice Fed a High-Fat Diet
• The Occurrence of Renin Inhibitor in Rice : Isolation, Identification, and Structure-Function Relationship
• Inhibition of E-Cadherin Dependent Cell-Cell Contact Promotes MUC5AC Mucin Production through the Activation of Epidermal Growth Factor Receptors
• Differentiation-Inducing Activity of Lupeol, a Lupane-Type Triterpene from Chinese Dandelion Root (Hokouei-kon), on a Mouse Melanoma Cell Line
• Isolation and functional analysis of a chk2 homologue from Entamoeba histolytica
• Induction of Apoptosis with an Extract of Actinidia polygama Fruit in the Promyelocytic Leukemia Cell Line HL-60
• Inhibitory Effect of Some Wild Plants in Akita on Melanin Biosynthesis
• In vitro screening for antihyperlipidemic activities in foodstuffs by evaluating lipoprotein profiles secreted from human hepatoma cells
• Lupeol Supplementation Improves Blood Pressure and Lipid Metabolism Parameters in Stroke-Prone Spontaneously Hypertensive Rats
• Lupeol Supplementation Improves Blood Pressure and Lipid Metabolism Parameters in Stroke-Prone Spontaneously Hypertensive Rats

もっと見る 閉じる

スポンサーリンク