Suppression of Murine Preadipocyte Differentiation and Reduction of Visceral Fat Accumulation by a Petasites japonicus Ethanol Extract in Mice Fed a High-Fat Diet

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概要

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• We investigated in this study the anti-obesity effect of an extract of Petasites japonicus (a culinary vegetable from Eastern Asia) on a murine adipocyte cell line (3T3-L1) and on diet-induced obesity-prone mice. An ethanol extract of P. japonicus. (PJET) suppressed 3T3-L1 preadipocyte differentiation; however, a hot water extract of P. japonicus (PJHW) exhibited no effect on cell differentiation. PJET significantly attenuated three adipogenetic transcription factors, peroxisome proliferator-activated receptor γ2, CCAAT/enhancer-binding protein and sterol regulatory element-binding protein 1C, at the mRNA level and suppressed the gene expression of fatty acid synthetase. An experiment with diet-induced obesity-prone C57BL/6J mice showed that PJET lowered the body weight gain and visceral fat tissue accumulation, and ameliorated the plasma cholesterol concentration. These findings suggest that P. japonicus might be an effective food against obesity.

著者

• Suzuki Nao

  Akita Research Institute for Food and Brewing (ARIF)

• HATA Keishi

  Akita Research Institute for Food and Brewing (ARIF)

• Hiwatashi Kazuyuki

  Akita Res. Inst. Of Food And Brewing

• HORI Kazuyuki

  Akita Research Institute of Food and Brewing

• WATANABE Takayuki

  Akita Research Institute for Food and Brewing

• ITOH Hideaki

  Faculty of Engineering and Resource Science, Akita University

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