Inhibitory Effects of Oxidized Low-density Lipoprotein on the Activity of Plasma Lecithin: Cholesterol Acyltransferase
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概要
- 論文の詳細を見る
Lecithin: cholesterol acyltransferase (LCAT) is an enzyme that is important in the cholesterol reverse-transport system by converting the surface cholesterol of high-density lipoprotein (HDL) to cholesterol ester inside HDL. We have investigated changes in plasma LCAT activity induced by oxidized low-density lipoprotein (ox-LDL). (i) LCAT activity was inhibited by the addition of even a small amount of ox-LDL, (ii) This inhibitory effect was dose-dependent and was related to the degree of oxidation of LDL, (iii) As this inhibitory effect was not prevented by antioxidants, it is suggested that it does not occur via oxidation of substrate HDL. These results suggest that cholesterol reverse-transport via HDL may be affected by ox-LDL and they are noteworthy in suggesting a new physiological function for ox-LDL.
- 社団法人日本農芸化学会の論文
- 1996-04-23
著者
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Furukawa Yuji
Laboratory Of Nutrition Department Of Applied Biological Chemistry Faculty Of Agriculture Tohoku Uni
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Kim Hyoun-ju
Laboratory Of Nutrition Department Of Applied Biological Chemistry Faculty Of Agriculture Tohoku Uni
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Kamiyama Shin
Laboratory Of Nutrition Department Of Applied Biological Chemistry Faculty Of Agriculture Tohoku Uni
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Kamiyama Shin
Laboratory Of Cell Biology Department Of Bioinformatics Faculty Of Engineering Soka University
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Furukawa Yuji
Laboratory Of Nutrition Department Of Applied Biological Chemistry Faculty Of Agriculture Tohoku Uni
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