Time-Dependent Change in Baroreflex Control Capacity of Arterial Pressure by Pentobarbital Anesthesia in Rabbits
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概要
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The present study is designed to investigate the time-dependent effect of pentobarbital anesthesia on the baroreflex arterial pressure (AP) control system in rabbits. The overall AP control capacity of the baroreflex system was assessed with mean arterial pressure (MAP) responses to the rapid mild hemorrhage (2 ml/kg body weight) and an overall open-loop gain (G) of the system. The G value was determined by means of the following formula: G=ΔAP I/ΔAPS-1, where ΔAP I is an immediate MAP fall and ΔAPS a steady-state fall after the rapid hemorrhage. Prior to the experiment, two catheters for AP measurement and hemorrhage were chronically in-dwelt in the aortic arch via the left subclavian and left common carotid arteries, respectively. Control mean arterial pressure averaged for 30 sec before the rapid hemorrhage (CMAP), ΔAP I and ΔAPS significantly increased and reached the maximal value at 14 min (CAMP: p<0.01) and 28 min (ΔAPI: p<0.01 and ΔAP S: p<0.01) after the intravenous injection of sodium pentobarbital in a 25.0 mg/kg dose, respectively. These values gradually decreased in the course of time and tended to recover to near the preanesthetic level at 77-98 min after the anesthesia. The G value significantly decreased from 7.3 in the conscious state to 1.5 at 28 min after the anesthesia (p<0.001), gradually increased with lapse of time and recovered to near the preanesthetic level at 77-98 min after the anesthesia. No significant difference in G was observed between in the conscious and anesthetized states beyond 70 min after the anesthesia (p>0.05). These findings suggest that pentobarbital sodium exerts a time-dependent inhibitory effect on the baroreflex system but does not significantly affect the overall AP control capacity of the baroreflex system itself at least 70 min after the intravenous administration at a dose of 25.0 mg/kg.
- 社団法人 日本実験動物学会の論文
著者
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SHIMIZU Tsuyoshi
Department of Cardiothoracic Surgery, The University of Tokyo
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WAKI Hidefumi
Department of Physiology, Wakayama Medical University, School of medicine
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Kimura Shuichi
Department Of Cellular And Integrative Physiology Fukushima Medical University School Of Medicine
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Shimizu Tsuyoshi
Shimizu Institute Of Space Physiology Suwa Maternity Clinic
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Shimizu Tsuyoshi
福島県立医科大学 医学部生理学
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KATSUDA Shin-ichiro
Department of Physiology, Fukushima Medical University School of Medicine
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Kimura Shuichi
Department Of Applied Biological Chemistry Faculty Of Agriculture Tohoku University
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YAMASAKI Masao
Department of Cellular and Integrative Physiology, Fukushima Medical University School of Medicine
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KATAHIRA Kiyoaki
Experimental Animal Research Center Fukushima Medical University School of Medicine
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O-ISHI Hirotaka
Department of Physiology, Fukushima Medical University School of Medicine
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NAGAYAMA Tadanori
Department of Physiology, Fukushima Medical University School of Medicine
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Katsuda S
Department Of Cellular And Integrative Physiology School Of Medicine Fukushima Medical University
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Kimura S
Laboratory Of Nutrition Graduate School Of Agricultural Science Tohoku University
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Waki Hidefumi
Department Of Physiology Fukushima Medical University School Of Medicine
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Yamasaki Masao
Department Of Cellular And Integrative Physiology Fukushima Medical University School Of Medicine
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Katsuda Shin-ichiro
Department Of Cellular And Integrative Physiology School Of Medicine Fukushima Medical University
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Yamasaki Masao
Department Of Biochemistry And Applied Biosciences Faculty Of Agriculture University Of Miyazaki
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Shimizu T
Shimizu Institute Of Space Physiology Suwa Maternity Clinic
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Shimizu Tsuyoshi
Department Of Cardiothoracic Surgery The University Of Tokyo
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Katahira Kiyoaki
Experimental Animal Center Fukushima Medical University School Of Medicine
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Nagayama Tadanori
Department Of Physiology Fukushima Medical University School Of Medicine
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Yamasaki Masao
Department Of Biochemistry And Applied Biosciences Faculty Of Agriculture Miyazaki University
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O-ishi Hirotaka
Department Of Physiology Fukushima Medical University School Of Medicine
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Kamiyama Shin
Gene Research Center Tohoku University
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