Important Role of β1-Integrin in Fucoidan-Induced Apoptosis via Caspase-8 Activation
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概要
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Fucoidan induces apoptosis by activating caspase-8 in human MCF-7 breast cancer cells, but the detailed mechanism for this is not understood. We demonstrate here that fucoidan interacted with the cell surface, and silencing the β1-integrin gene expression inhibited fucoidan-induced apoptosis accompanied by caspase-8 activation. Fucoidan induced formation of the β1-integrin-caspase-8 complex. These data indicate that β1-integrin is an important factor for the cell-surface binding of fucoidan and plays an important role in fucoidan-induced apoptosis. Fucoidan also induced recruitment of caspase-8 to the β1-integrin intracellular domain, cleaved it into the activated protein by direct combination with β1-integrin, and induced apoptosis via the caspase cascade in MCF-7 cells.
著者
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TACHIBANA Hirofumi
Department of Bioscience and Biotechnology, Division of bioresource and Bioenvironmental Sciences, G
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Miyazaki Yoshiyuki
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Tachibana Hirofumi
Department Of Food Science And Technology Faculty Of Agriculture Kyushu University
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Yamasaki Masao
Department Of Biochemistry And Applied Biosciences Faculty Of Agriculture Miyazaki University
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Yamada Koji
Deparment Of Food Science And Technology Faculty Of Agriculture Kyushu University
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Yamasaki Yumi
Department Of Bioscience And Biotechnology Faculty Of Agriculture Kyushu University
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