Enzymatic Sulfation of Tocopherols and Tocopherol Metabolites by Human Cytosolic Sulfotransferases
スポンサーリンク
概要
- 論文の詳細を見る
Tocopherols are essential micronutrients for mammals widely known as potent lipid-soluble antioxidants that are present in cell membranes. Recent studies have demonstrated that most of the carboxychromanol (CEHC), a tocopherol metabolite, in the plasma exists primarily in sulfate- and glucuronide-conjugated forms. To gain insight into the enzymatic sulfation of tocopherols and their metabolites, a systematic investigation was performed using all 14 known human cytosolic sulfotransferases (SULTs). The results showed that the members of the SULT1 family displayed stronger sulfating activities toward tocopherols and their metabolites. These enzymes showed a substrate preference for γ-tocopherol over α-tocopherol and for γ-CEHC over other CEHCs. Using A549 human lung epithelial cells in a metabolic labeling study, a similar trend in the sulfation of tocopherols and CEHCs was observed. Collectively, the results obtained indicate that SULT-mediated enzymatic sulfation of tocopherols and their metabolites is a significant pathway for regulation of the homeostasis and physiological functions of these important compounds.
- 社団法人 日本農芸化学会の論文
著者
-
LIU Ming-Cheh
Department of Pharmacology, College of Pharmacy, The University of Toledo
-
SUIKO Masahito
Department of Biochemistry and Applied Biosciences, University of Miyazaki
-
Yasuda Shin
Department Of Bioscience School Of Agriculture Tokai University
-
Sakakibara Yoichi
Department Of Biochemistry And Applied Biosciences Faculty Of Agriculture University Of Miyazaki
-
Sakakibara Yoichi
Department Of Forest Science And Resources College Of Bioresource Sciences Nihon University
-
Kurogi Katsuhisa
Department Of Biochemistry And Applied Biosciences University Of Miyazaki
-
Nishiyama Kazuo
Department Of Biological Resource Sciences Miyazaki University
-
Yamasaki Masao
Department Of Biochemistry And Applied Biosciences Faculty Of Agriculture Miyazaki University
-
HASHIGUCHI Takuyu
Department of Biochemistry and Applied Biosciences, University of Miyazaki
関連論文
- Inhibitory Effects of Nitrative Stress on the Sulfation of 17β-Estradiol and 4-Methoxyestradiol by Human MCF 10A Mammary Epithelial Cells
- 味覚センサを用いた本格焼酎の味評価
- 疾病環境における硫酸転移酵素とそのはたらき
- Molecular Cloning, Expression and Characterization of A Novel Mouse SULT6 Cytosolic Sulfotransferase
- 3S4a01 プロテオミクスを基盤としたハイスループット食品機能性評価法開発を目指して(ポストトランスクリプトミクス研究の最前線,シンポジウム)
- 3Ga01 マウス硫酸転移酵素SULT2B1のC末端付加配列の機能解明(酵素学,酵素工学,タンパク質工学,糖鎖工学,一般講演)
- 抗変異原活性をもつ宮崎県産農産物の探索
- 3I11-1 本格焼酎用酵母のプロテオーム解析(ペプチド工学・プロテオーム,糖鎖工学,一般講演)
- Differential Enzymatic Characteristics and Tissue-Specific Expression of Human TPST-1 and TPST-2
- 細胞質硫酸転移酵素と環境中のエストロジェン様化合物
- 本格焼酎の基本味を識別する脂質膜センサ
- Retronasal Aroma Simulator を用いた穀類本格焼酎の含み香と立ち香分析
- 生物が獲得した無機硫酸の賢い利用法:硫酸転移酵素による解毒代謝機構
- Cloning and Expression of a Novel Trichoderma viride Laminarinase AI Gene (lamAI)
- 翻訳後修飾としてのチロシン硫酸化の機能解明 : Tyrosylprotein sulfotransferase の生化学的諸性質の検討
- 蕎麦焼酎の特徴香および穀類本格焼酎の揮発性成分分析
- Purification and Characterization of Laminaran Hydrolases from Trichoderma viride(Microbiology & Fermentation Technology)
- Differential Roles of Human Monoamine (M)-Form and Simple Phenol (P)-Form Phenol Sulfotransferases in Drug Metabolism
- 3P-1059 ニューロステロイド硫酸転移酵素の諸性質の検討(2a酵素学,酵素工学,一般講演,酵素学,タンパク質工学および酵素工学,伝統の技と先端科学技術の融合)
- 2S-Dp03 化合物の構造情報を必要としない食品成分の網羅的な機能性評価法(食の機能・安全を科学する-おいしさから生理活性,安全性の評価まで,シンポジウム,伝統の技と先端科学技術の融合)
- 2P-1147 マススペクトルを用いた有用酵母の迅速同定・選抜法(4a醸造学,醸造工学,一般講演,醸造・食品工学,伝統の技と先端科学技術の融合)
- Relationship between the Structures and Cytotoxic Activities of 1, 3, 4-Thiadiazolo[3, 2-α]pyrimidines
- 2P-1145 従来の生理学的・形態学的手法に依存しない本格焼耐用酵母スクリーニング法の開発(4a醸造学,醸造工学,一般講演,醸造・食品工学,伝統の技と先端科学技術の融合)
- 2P-1146 プロテオーム解析による有用酵母の分類・同定技術開発(4a醸造学,醸造工学,一般講演,醸造・食品工学,伝統の技と先端科学技術の融合)
- Effect of Dietary Conjugated Linoleic Acid on Liver Regeneration after a Partial Hepatectomy in Rats
- PE-245 Impact of Donor-transmitted Atherosclerosis on Early Cardiac Allograft Vasculopathy : New Findings by Volumetric IVUS Analysis(PE041,Transplantation/LVAD (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation So
- Production, Purification and Properties of an Endoinilinase of Penicillium sp. TN-88 That Liberates Inulotriose
- 内分泌攪乱物質と硫酸転移酵素の密接な関係硫酸化により"環境ホルモン"を排泄する機構
- HepG2細胞マンガン依存性ドーパ/チロシン硫酸転移酵素の諸性質及びモノアミンフォームフェノール硫酸転移酵素としての同定
- ラット肝臓のドーパ・チロシン硫酸転移酵素のcDNAクローニングと発現 : 酵素
- Deep-Sea Water Improves Cardiovascular Hemodynamics in Kurosawa and Kusanagi-Hypercholesterolemic (KHC) Rabbits(Pharmacology)
- Effects of microgravity on organ development of the neonatal rat
- Effects of Space Flight on the Histological Characteristics of the Aortic Depressor Nerve in the Adult Rat : Electron Microscopic Analysis
- Effects of parabolic flight on abdominal arterial pressure in conscious rats
- Morphological characteristics of the kidney and lung in the neonatal rats observed after 16 days spaceflight
- Postnatal Changes in the Rheological Properties of the Aorta in Sprague-Dawley Rats
- Time-Dependent Change in Baroreflex Control Capacity of Arterial Pressure by Pentobarbital Anesthesia in Rabbits
- A Novel Fermented Food Product Prepared from Soybean Protein-Calcium-Gel with Monascus Fungus : Changes in Protein and Nitrogen Compounds during Fermentation
- On the Sulfation and Methylation of Catecholestrogens in Human Mammary Epithelial Cells and Breast Cancer Cells(Miscellaneous)
- Transient Prevention of Ethanol-Induced Gastric Lesion by Capsaicin Due to Release of Endogenous Calcitonin Gene-Related Peptide in Rats
- Role of endogenous substance P in ethanol-induced mucosal damage in the rat stomach
- 蕎麦焼酎揮発性成分の抗変異原性と抗酸化作用
- 硫酸転移酵素を用いた変異原試験法における食品の機能性評価に関する研究
- PJ-171 High Potassium Diet Prevents Increased Connective Tissue Growth Factor mRNA in the Kidney of Salt-loaded, Dahl Salt-sensitive Rats.(Hypertension, Basic 1 (H) : PJ29)(Poster Session (Japanese))
- PPARγ Activator, Troglitazone, Inhibits TNF-α-Induced LOX-1 mRNA Level in Murine Aorta
- Adrenomedullin Inhibits Arterial Intimal Formation Induced by Cuff Placement through a NO-Dependent Pathway of eNOS
- Inhibition of TNF- α -Induced LOX-1 Expression by PPAR γ Activators in Bovine Aortic Endothelial Cells
- Adrenomedullin Overexpression to Limit Arterial Intimal Formation Induced by Cuff Placement
- Novel Screening Method for Potential Skin-Whitening Compounds by a Luciferase Reporter Assay
- Performances of Four Chemicals with Floral Scents as Attractants for Longicorn Beetles (Coleoptera: Cerambycidae) in a Broadleaved Forest
- Reduced Expression of Perchloric Acid-Soluble Protein after Partial Hepatectomy in Rats
- Primitive Stem Cell and Its Pathogenesis of Intracoronary Thrombi in ACS Patients(Thrombosis/Thrombolysis 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Temporal Analysis of Cellular Constituents of Intracoronary Thrombi in ACS Patients Aspirated Through Thrombectomy(Acute Coronary Syndrome, Basic/Clinical 4 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Structure-Activity Relationship of Immunoregulatory Factors in Foodstuffs
- Soy-derived isoflavones inhibit the growth of adult T-cell leukemia cells in vitro and in vivo
- Molecular Cloning,Expression,and Characterization of a Novel Mouse Liver SULT1B1 Sulfotransferase
- cDNA Cloning, Expression, and Characterization of the Human Bifunctional ATP Sulfurylase/Adenosine 5'-Phosphosulfate Kinase Enzyme
- Purification and Characterization of Adenosine 5'-Phosphosulfate Kinase from the Thermophilic Bacterium Bacillus stearothermophilus
- 中国餅麹(曲)由来の新規黒色系糸状菌の焼酎醸造特性
- The Biological and Structural Similarity between Lunularic Acid and Abscisic Acid(Organic Chemistry)
- 薬物代謝と農薬の効能--特に硫酸化について (農薬バイオフロンティア--脱石油社会の基幹産業を担う必須の農業資材・農薬とは)
- Prostaglandin E_2 produced by late induced COX-2 stimulates hippocampal neuron loss after seizure in the CA3 region
- Running fit and geralized tonic-clonic seizure are differently controlled by differently subtypes receptors in the brain stem (vol. 2)
- Preparation of 3'-Phosphoadenosine 5'-Phospho^S-sulfate Using ATP Sulfurylase and APS Kinase from Bacillus stearothermophilus: Enzymatic Synthesis and Purification
- Regulatory Effects of Divalent Metal Cations on Human Cytosolic Sulfotransferases
- フェノール硫酸転移酵素遺伝子ファミリーの機能と構造
- 硫酸転移酵素 遺伝子および機能の多様性
- Manganese Administration Induces the Increased Production of Dopamine Sulfate and Depletion of Dopamine in Sprague-Dawley Rats^1
- Structural Identification of Sulfated Tyrosine in Human Urine
- Substrate Specificity of Human Monoamin(M)-Form Phenol Sulfotransferase: Preparation and Analysis of Dopa 3-O-Sulfate and Dopa 4-O-Sulfate
- 尿及び血清中の硫酸化チロシンの定性 : 酵素
- Desulfation of Tyrosine-0-sulfated Peptides by Some Eukaryotic Sulfatases
- Novel Screening Method for Potential Skin-Whitening Compounds by a Luciferase Reporter Assay
- Mustard Oil in "Shibori Daikon" a Variety of Japanese Radish, Selectively Inhibits the Proliferation of H-ras-Transformed 3Y1 Cells
- Genistein Induced Apoptotic Cell Death in Adult T-Cell Leukemia Cells through Estrogen Receptors
- Sulforaphane Inhibited Melanin Synthesis by Regulating Tyrosinase Gene Expression in B16 Mouse Melanoma Cells
- Temporal and Spatial Variations in Electron Density and Blackbody Temperature in the Initial Phase of a Laser Ablation BN Plasma
- Boring Activity on Coniferous Tree Branches by Xylotrechus villioni (Villard) Larvae (Coleoptera: Cerambycidae)
- 薬物代謝と農薬の効能 : 特に硫酸化について(農薬バイオフロンティア-脱石油社会の基幹産業を担う必須の農業資材・農薬とは-)
- ホ乳動物細胞におけるL-チロシンの硫酸化について : 酵素
- Evaluation of Beetle Capture in Traps as Compared with Manual Capture on Flowers in a Long-term Investigation in a Beech Forest
- Comparison of Beetle Samples Captured by Traps with Those on Flowers in a Broad-leaved Forest
- Characterization of Bovine Heart Sulfotransferase Catalyzing the Sulfation of Tyrosine-Containing Peptides
- プロテオーム解析による食品機能の研究(食の機能・安全を科学する-おいしさから生理活性,安全性の評価まで)
- 食品成分の網羅的な機能性評価法(食の機能・安全を科学する-おいしさから生理活性,安全性の評価まで)
- Enzymatic Sulfation of Tocopherols and Tocopherol Metabolites by Human Cytosolic Sulfotransferases
- Inhibition of proliferation by agricultural plant extracts in seven human adult T-cell leukaemia (ATL)-related cell lines
- 3S3a02 二次元電気泳動を基盤にしたプロテオミクス技術の裏技(オミックス解析技術の裏技紹介:生物工学分野への応用,ワークショップ)
- Enzymatic Sulfation of Tocopherols and Tocopherol Metabolites by Human Cytosolic Sulfotransferases
- タンパク質の翻訳後修飾としてのチロシン硫酸化
- プロテオーム解析による食品機能の研究
- タンパク質の翻訳後修飾としてのチロシン硫酸化
- Selective Inhibition by Apocynin of the Proliferation and Adhesion to Fibronectin of v-H-ras-Transformed 3Y1 Cells
- Ethanol Sulfation by the Human Cytosolic Sulfotransferases: A Systematic Analysis
- DNA Breakage by Hydrolyzable Tannins in the Presence of Cupric Ion
- DNA Breakage by Phenyl Compounds
- Evaluation of the Effects of Freezing on the Preservation of Fresh Shiitake Fruit Bodies and Lenthionine Formation after Thawing.
- Anti-Inflammatory and Antioxidative Effects of a Methanol Extract from Bulbs of Scilla scilloides
- Molecular Cloning, Expression, and Characterization of a Novel Mouse Liver SULT1B1 Sulfotransferase.
- Sulfation of ractopamine and salbutamol by the human cytosolic sulfotransferases