Pharmacokinetics of Zonisamide ; Saturable Distribution into Human and Rat Erythrocytes and into Rat Brain
スポンサーリンク
概要
- 論文の詳細を見る
The distribution of zonisamide, a new antiepileptic drug, in erythrocytes and in brain was studied to clarify the factors influencing its distribution in epileptic patients. In both humans and rats, zonisamide was concentrated significantly in erythrocytes in a saturable manner. When the effective concentration of zonisamide in serum was compared with that in blood in nine refractory epileptic patients taking zonisamide chronically, the variation in effective serum concentration was significantly larger than that in blood concentration. In rats, the distribution in the brain also showed saturability. These results suggest that differences in saturable binding to various tissues may contribute to the wide variation that occurs in the effective serum concentration of zonisamide in epileptic patients and that monitoring of the blood concentration of zonisamide may provide useful information for treatment with this drug.
- 公益社団法人日本薬学会の論文
著者
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OKUMURA Katsuhiko
Department of Hospital Pharmacy, Kobe University School of Medicine
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Ohnishi N
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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NAKAMURA Hajime
Department of Pediatrics, Kobe University School of Medicine
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YAGI Jiro
Department of Metallurgical Engineering, Faculty of Engineering, Chiba Institute of Technology
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Nishiguchi Kohshi
Department of Hospital Pharmacy, School of Medicine, Kobe University
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OHNISHI Noriaki
Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University
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YOKOYAMA Teruyoshi
Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University
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IWAKAWA Seigo
Kobe Pharmaceutical University
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Okumura K
Department Of Clinical Evaluation Of Pharmacotherapy Kobe University Graduate School Of Medicine
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Nakamura H
Kobe Univ. School Of Medicine Kobe Jpn
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IWAKAWA Seigo
Department of Pharmaceutics, Kobe Pharmaceutical University
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Yagami Tatsurou
2shionogi Research Laboratories Shionogi & Co. Ltd.
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Iwakawa S
Department Of Cardiology Miki
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Iwakawa Seigo
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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Yokoyama T
Kitasato Univ. Sagamihara Jpn
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Yokoyama Teruyoshi
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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Nishiguchi K
Department Of Hospital Pharmacy Kobe University School Of Medicine
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Nishiguchi Kohshi
Department Of Clinical Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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Nishiguchi Kohshi
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Okumura Katsuhiko
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Ohnishi Noriaki
Department Of Applied Fine Chemistry Faculty Of Engineering Osaka University
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TAKADA SATOSHI
Department of Urology, Nara Medical University
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NAKAYAMA Shinichi
Departments of Hospital Pharmacy Pediatrics
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Okumura Katsuhiko
Department Of Clinical Evaluation Of Pharmacotherapy Kobe University Graduate School Of Medicine
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Yagi Jiro
Departments Of Hospital Pharmacy Pediatrics : School Of Medicine Kobe University : Department Of Hos
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Yagi Jiro
Department Of Metallurgical Engineering Faculty Of Engineering Chiba Institute Of Technology
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Shinobu Ichikawa
Department Of Cardiology Miki
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Takada S
Departments Of Hospital Pharmacy Pediatrics : School Of Medicine Kobe University : Department Of Hos
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Takada Satoshi
Department Of Applied Biology Faculty Of Textile Science And Technology Shinshu University
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Nakayama Shinichi
Departments Of Hospital Pharmacy Pediatrics : School Of Medicine Kobe University : Department Of Hos
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Nagahiro Kazumi
Department Of Hospital Pharmacy Kobe University School Of Medicine
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Nakamura Hajime
Department Of Biological Responses Institute For Virus Research Kyoto University
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Ichikawa Shinobu
Department Of Cardiology Miki City Hospital
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Nakayama Shinichi
Department Of Pediatrics Kakogawa City Hospital
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NAKAYAMA Shinichi
Department of Nuclear Engineering, Faculty of Engineering,Kyoto University
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Iwakawa Seigo
Department of Cardiology, Miki
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