Studies on Interactions between Traditional Herbal and Western Medicines.V. Effects of Sho-saiko-to (Xiao-Cai-hu-Tang) on the Pharmacokinetics of Carbamazepine in Rats
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概要
- 論文の詳細を見る
The possibility of pharmacokinetic interactions between Sho-saiko-to extract powder (TJ-9), the most widely used traditional Chinese herbal (Kampo) medicine in Japan, and carbamazepine (CBZ), an important anti-epileptic drug, was examined in rats. There was no significant difference in the protein binding of CBZ in serum obtained before and after the single oral administration of TJ-9. The addition of TJ-9 to normal hepatic microsomes inhibited CBZ-10,11-epoxylase activity in a concentration-dependent manner. Liver weight, amounts of P450 and cytochrome b5 in hepatic microsomes and the formation of carbamazepine-10,11-epoxide (CBZ-E), an active metabolite of CBZ, by microsomes were not influenced by 2-week repeated oral pretreatment with TJ-9 (1g/kg/d), although pretreatments with phenobarbital (80mg/kg/d, i.p.) significantly increased these parameters. The simultaneous oral administration of TJ-9 (1g/kg) significantly decreased the peak plasma concentration of CBZ and the area under the concentration-time curve of CBZ-E, and lengthened the time to reach the peak concentration of CBZ after oral administration of CBZ. Two-week repeated oral pretreatment with TJ-9, however, did not affect the plasma concentration-time profile or any pharmacokinetic parameter of CBZ or CBZ-E. Also, a single oral administration of TJ-9 (1g/kg) significantly delayed gastric emptying. These results indicated that the simultaneous oral administration of TJ-9 with CBZ to rats decreased the gastrointestinal absorption of CBZ, at least in part, by delaying gastric emptying, without affecting the metabolism of CBZ.
- 公益社団法人日本薬学会の論文
- 2002-11-01
著者
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KURODA Kazuo
Institute of Industrial Science, University of Tokyo
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Ohnishi N
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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Kimura T
Kobe University Graduate School Of Medicine
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Takara Kohji
Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University
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OHNISHI Noriaki
Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University
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YOKOYAMA Teruyoshi
Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University
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OKADA KAZUYA
Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences
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Okada K
Nucleo De Pesquisas Em Ciencias Ambientais Universidade Catolica De Pernambuco
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Takara Kohji
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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Takara Kohji
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Okada Kazuya
Department Of Biology Faculty Of Science Nagoya University
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Yagami Tatsurou
2shionogi Research Laboratories Shionogi & Co. Ltd.
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YOSHIOKA Mutsunobu
Department of Pharmacy, Takarazuka City Hospital
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TAKARA Koji
Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University
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KURODA Kazuo
Department of Pharmacy, Takarazuka City Hospital
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NAGASAWA Kazuki
Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University
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Yokoyama T
Kitasato Univ. Sagamihara Jpn
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Yokoyama T
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Yokoyama Teruyoshi
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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Ohnishi Noriaki
Department Of Applied Fine Chemistry Faculty Of Engineering Osaka University
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Kuroda K
Department Of Pharmacy Takarazuka City Hospital
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Nagasawa Kazuki
Institute Of Molecular And Cellular Biosciences The University Of Tokyo
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Nagasawa Kazuki
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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Nagasawa Kazuki
Department Of Environmental Biochemistry Kyoto Pharmaceutical University
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Koishi Tomokazu
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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Yoshioka Mutsunobu
Department Of Pharmacy Takarazuka City Hospital
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Kuroda Kazuo
Department Of Pharmacy Takarazuka City Hospital
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