MDR1 Gene Polymorphism in Japanese Patients with Schizophrenia and Mood Disorders Including Depression(Biopharmacy)
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概要
- 論文の詳細を見る
P-Glycoprotein (ABCB1-type P-gp), a membrane protein encoded by the multi drug resistant gene (MDR1), expressing on the blood brain barrier protects the brain from many drugs including dexamethasone. Psychiatric disorders, schizophrenia and depression, have known to have abnormal hypothalamus-pituitary-adrenal (HPA) activity, which is assessed by non-suppression of cortisol in dexamethasone suppression test. The poor response to dexamethasone in these patients' population suggested the impaired activity on dexamethasone penetration into the brain via P-gp, which was associated with MDR1 polymorphisms. We, therefore, examined five SNPs of the MDR1 gene, -1517T>C (promoter), -41A>G (intron -1), -129T>C (exon 1b), 2677G>A,T (exon 21) and 3435C>T (exon 26), in Japanese patients with schizophrenia (n=121) and mood disorders (n=62), and compared with the control subjects (n=160). The frequency of MDR1 mutant alleles at -1517, -41 and -129 in patients with mood disorders was significantly lower (2.4, 5.6, 2.4%, respectively) than those of controls (7.8, 13.7, 7.8%, respectively) (p<0.05). The frequencies of MDR1 2677 G/A and A/A genotype in mood disorders was significantly higher (17.7, 6.5%, respectively) than controls (11.2, 0%, respectively) (p<0.05). The 2677A allele frequency in mood disorders (20.2%) was significant higher than controls (10.9%) (p<0.05). Haplotype of 129-2677-3435 (T-A-C) in mood disorders was significantly higher (14.4%) than controls (8.0%) (p<0.05). There was no significant difference in allele and genotype frequencies between the patients with schizophrenia and controls. These findings suggested that predispose to mood disorders, not schizophrenia, was associated with possible alteration of P-gp activities corresponding MDR1 polymorphism at least partly.
- 社団法人日本薬学会の論文
- 2006-12-01
著者
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Ohkohchi Nobuhiro
Department Of Surgery Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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HONDA Katsuya
Department of Mathematical Sciences, Shinshu University
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Ohnishi N
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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INOMATA Shinichi
Department of Anesthesiology and Critical Care Medicine, University of Tsukuba
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Yoshida Kentaro
筑波大学 循環器内科
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Yoshida Kentarou
東京女子医科大学 循環器内科学
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Kobayashi H
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Hirai M
Kobe Pharmaceutical University
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QIAN Wen
Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University o
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HOMMA Masato
Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University o
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ITAGAKI Fumio
Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University o
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TACHIKAWA Hirokazu
Department of Clinical Neuroscience, Graduate School of Comprehensive Human Sciences, University of
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KAWANISHI Yoichi
Department of Clinical Neuroscience, Graduate School of Comprehensive Human Sciences, University of
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MIZUKAMI Katsuyoshi
Department of Clinical Neuroscience, Graduate School of Comprehensive Human Sciences, University of
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ASADA Takashi
Department of Clinical Neuroscience, Graduate School of Comprehensive Human Sciences, University of
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KOHDA Yukinao
Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University o
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Qian Wen
Department Of Hematology The First Affiliated Hospital College Of Medicine Zhejiang University
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Qian Wen
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Homma M
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Homma Masato
Department Of Clinical Pharmacology Institute Of Cliniical Medicine University Of Tsukuba
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Itagaki Fumio
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Horinouhi Masanori
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Kohda Yukinao
Department Of Pharmacy Tsukuba University Hospital:department Of Pharmaceutical Sciences Graduate Sc
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Kohda Yukinao
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Honda Katsuya
Department Of Applied Physics Faculty Of Engineering Nagoya University
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Inomata Shinichi
Department Of Anesthesiology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Inomata Shinichi
Department Of Anesthesia Mito Saiseikai General Hospital
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Kohda Y
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Homma Masato
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Asada Takashi
Department Of Clinical Neuroscience Graduate School Of Comprehensive Human Sciences University Of Ts
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Mizukami Katsuyoshi
Department Of Psychiatry Institute Of Clinical Medicine University Of Tsukuba
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Mizukami Katsuyoshi
Department Of Clinical Neuroscience Graduate School Of Comprehensive Human Sciences University Of Ts
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Kohda Yukinao
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Kakiuchi Yoshihiro
Department Of Clinical Neuroscience Graduate School Of Comprehensive Human Sciences University Of Ts
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Tachikawa Hirokazu
Department Of Clinical Neuroscience Graduate School Of Comprehensive Human Sciences University Of Ts
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Asada Takashi
Department Of Clinical Neuroscience Graduate School Of Comprehensive Human Sciences University Of Ts
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Kohda Yukinao
Department Of Cardiology University Of Tsukuba Graduate School Of Comprehensive Human Sciences
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Asada Takashi
Department of Cardiovascular Medicine, Clinical Laboratory, National Cerebral and Cardiovascular Center
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ASADA TAKASHI
Department of Applied Chemistry, Gufu University
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OHKOHCHI Nobuhiro
Department of Organ Transplantation Gastroenterological and Hepatobiliary Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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