Characteristics of Delayed Excretion of Flavonoids in Human Urine after Administration of Shosaiko-to, a Herbal Medicine
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概要
- 論文の詳細を見る
There has been little explanation of herbal medicines by modern medical sciences, including pharmacokinetics, whereas physicians follow empirical indications written in classical literature. Recent reports of herb-induced adverse reactions compelled us to proceed the investigation of a herbal medicine Shosaiko-to (TJ-9) from a pharmacokinetic point of view.To five healthy volunteers, a single 5g dose of TJ-9,consisting of 7 herbs, was administered. We conducted HPLC analysis of the timed-urine specimens to disclose the type and amount of compounds excreted. Excretion rate-time curves were analyzed individually.Four flavonoids, liquiritigenin, baicalein, wogonin and oroxylin A, were found both in the urine and TJ-9. The glycosides in TJ-9 were absorbed after microflora hydrolysis. Davidigenin, which was not found in TJ-9,was an intestinal metabolite of liquiritigenin. Also, two flavanones, S-dihydrowogonin and S-dihydrooroxylin A, were identified as the metabolites of wogonin and oroxylin A, respectively. Excretion rate-time curves of the flavonoids were divided into three types of structure-dependent absorption, i.e. (1) the fast absorption of herbal-origin aglycons, (2) the moderately-delayed absorption of aglycons derived from herbal glycosides, and (3) markedly-delayed absorption after the molecular transformation of herbal compounds.Individual excretion profiles seemed to depend on microflora activities. Two types of flavonones, S-dihydrowogonin and S-dihydrooroxylin A, were found in a half of the volunteers, suggesting there might be two kinds of volunteers, namely, rapid and poor metabolizers of flavonoids.
- 公益社団法人日本薬学会の論文
- 1998-12-15
著者
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OKA Kitaro
Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Sciences
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Hirai M
Kobe Pharmaceutical University
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HOMMA Masato
Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University o
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Oka Kitaro
Department Of Clinical Pharmacology School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Oka Kitaro
Department Of Clinical Pharmacology Tokyo University Of Pharmacy And Life Science
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Oka Kitaro
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Li Chuan
Department Of Life Sciences Chung Shan Medical University
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Oka K
Department Of Clinical Pharmacology School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Homma M
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Homma Masato
Department Of Clinical Pharmacology Institute Of Cliniical Medicine University Of Tsukuba
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Horinouhi Masanori
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Li Chuan
Department Of Clinical Pharmacology School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Li Chuan
Institute Of Medicine Chung Shan Medical And Dental University
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Homma Masato
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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