False Positive Blood Tacrolimus Concentration in Microparticle Enzyme Immunoassay
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概要
- 論文の詳細を見る
The difference in the blood concentration of tacrolimus between the assay methods, microparticle enzyme immunoassay (MEIA) and enzyme linked immunosorbent assay (ELISA) was observed in a liver transplant recipient with anemia. MEIA provided significantly higher concentration than those of ELISA (7.8±1.9 vs. 5.0±1.8 ng/ml, p<0.05) while the patient had low haematocrit <25%. The difference, however, was not observed during the periods with haematocrit >25%. This observation suggested that unknown tacrolimus levels generated from difference in assay methods gave incorrect blood tacrolimus during anemia. False positive concentration of tacrolimus ranging 0.1-3.3 ng/ml was observed in MEIA applying to the blood samples obtained from the patients without receiving tacrolimus. The false positive tacrolimus increased in the samples with lower hematocrit, suggesting that MEIA gave incorrect blood tacrolimus during anemia. Since MEIA potentially overestimates the tacrolimus levels, ELISA should be used for blood tacrolimus monitoring in the patients with anemia.
- 公益社団法人日本薬学会の論文
- 2002-08-01
著者
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TAKADA Yasutsugu
Department of Surgery, Graduate School of Medicine, Kyoto University
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Yoshida Kentaro
筑波大学 循環器内科
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Yoshida Kentarou
東京女子医科大学 循環器内科学
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Hirai M
Kobe Pharmaceutical University
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HOMMA Masato
Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University o
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KOHDA Yukinao
Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University o
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Tomita T
Department Of Pharmacy Tsukuba University Hospital:department Of Medicinal Information School Of Pha
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YUZAWA KENJI
Departments of Surgery, Division of Gastroenterology, Institute of Clinical Medicine, University of
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Homma M
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Homma Masato
Department Of Clinical Pharmacology Institute Of Cliniical Medicine University Of Tsukuba
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Horinouhi Masanori
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Kohda Yukinao
Department Of Pharmacy Tsukuba University Hospital:department Of Pharmaceutical Sciences Graduate Sc
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Kohda Yukinao
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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TOMITA Takashi
Department of Pharmacy, Tsukuba University Hospital
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Yuzawa Kenji
Departments Of Surgery Division Of Gastroenterology Institute Of Clinical Medicine University Of Tsu
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Yuhara Kyoko
Departments Of Internal Medicine University Of Tsukuba
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Yuzawa Kenji
Department Of Surgery Institute Of Clinical Medicine University Of Tsukuba
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Tomita Takashi
Department Of Medical Entomology National Institute Of Infectious Diseases
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Kohda Y
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Takada Yasutsugu
Department Of Hepato-biliary-pancreatic Surgery And Transplantation Kyoto University
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Homma Masato
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Kohda Yukinao
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Tomita Takashi
Department Of Electric And Electronic Engineering Toyohashi University Of Technology
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Kohda Yukinao
Department Of Cardiology University Of Tsukuba Graduate School Of Comprehensive Human Sciences
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TAKADA Yasutsugu
Department of Surgery Institute of Clinical Medicine, University of Tsukuba
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